Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 1-10 of 2,317 results
Neural Regen Res, 2025 • November 1, 2025
The review explores the applications of MSCs and MSC-exosomes in repairing PNI, discussing the underlying mechanisms and comparing the therapies. It summarizes preclinical investigations and clinical ...
KEY FINDING: MSCs contribute to nerve regeneration via various mechanisms, including differentiating into Schwann cell-like cells, which support axonal growth and clear debris.
Neural Regeneration Research, 2025 • October 22, 2024
Peripheral nerve injury (PNI) results in multilevel pathological changes affecting the central nervous system (CNS), peripheral nervous system (PNS), and target organs, requiring a holistic treatment ...
KEY FINDING: Peripheral nerve injury induces a series of changes from the central nervous system to the peripheral nervous system and target organs, impacting cortical plasticity, spinal cord neurons, and muscle tissue.
Regenerative Therapy, 2024 • September 23, 2024
This study investigates a novel approach to spinal cord injury treatment by combining the anti-inflammatory properties of Laurus nobilis extract (LNE) with the regenerative capabilities of adipose-der...
KEY FINDING: Laurus nobilis extract-loaded scaffolds reduced tissue expression levels of pro-inflammatory cytokines like TNF-a, IL-1b, and IL-6.
Neural Regeneration Research, 2023 • April 1, 2023
This review summarizes the progress in reprogramming astrocytes into neurons in vivo in animal models of various CNS conditions. The focus is on spinal cord injury, brain injury, Huntington’s disease,...
KEY FINDING: Astrocytes in the mature CNS can be reprogrammed into functional neurons in vivo, offering a potential avenue for nerve regeneration.
Neural Regeneration Research, 2023 • October 10, 2022
The study investigated the effect of double-target NC-MS on rats with incomplete SCI, finding that it improved motor function and promoted recovery of the descending motor pathway. NC-MS treatment att...
KEY FINDING: Double-target NC-MS treatment improved motor function in rats with incomplete SCI, as evidenced by increased BBB scores and inclined-plane angles.
Neural Regen Res, 2023 • May 1, 2023
This study demonstrates that combining bone marrow mesenchymal stem cell (BMMSC) transplantation with exercise training (TMT) synergistically improves motor function recovery in mice after spinal cord...
KEY FINDING: The combination of bone marrow mesenchymal stem cell transplantation and exercise training showed a better therapeutic effect on motor function than the single treatments.
Neural Regeneration Research, 2023 • November 25, 2022
The study investigated the effects of exercise combined with adipose-derived stem cells (ADSCs) on neuropathic pain after spinal cord injury (SCI) in a mouse model. The results demonstrated that the c...
KEY FINDING: Exercise combined with ADSC administration partially improved early motor function recovery after SCI.
J Physiol, 2023 • June 1, 2023
This study investigates the effects of SPG302, a novel regenerative drug, on diaphragm muscle (DIAm) function following cervical spinal cord hemisection (C2SH) in rats. The researchers assessed DIAm e...
KEY FINDING: C2SH causes marked EMG deficits across ventilatory behaviours
Cellular and Molecular Neurobiology, 2023 • March 13, 2023
This study investigates the therapeutic potential of inhibiting Chst15, an enzyme controlling the biosynthesis of inhibitory chondroitin sulfate-E (CS-E), for spinal cord injury (SCI) treatment. The r...
KEY FINDING: Inhibition of Chst15 impairs the deposition of CSPGs in the extracellular matrix and the migration of astrocytes, which are key processes in glial scar formation after SCI.
Neural Regen Res, 2023 • January 30, 2023
Spinal cord injury leads to neuronal death, with ferroptosis being a key contributor to dysfunction. Emerging treatments like MSC, EV, and TMS therapy offer hope by potentially inhibiting neuronal dea...
KEY FINDING: Ferroptosis, a form of cell death, significantly contributes to neurological dysfunction following spinal cord injury.