Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,291-2,300 of 2,317 results
International Journal of Molecular Sciences, 2016 • December 26, 2016
Stem cells represent a promising therapeutic approach for SCI, enhancing sensory and motor functions in animal models by promoting remyelination and axonal regeneration. Challenges remain in stem cell...
KEY FINDING: Stem cells can promote remyelination, neurite outgrowth, and axonal elongation after spinal cord injury.
Biol Bull, 2011 • August 1, 2011
This paper discusses the use of functional genomics and gene network analysis to study regeneration, focusing on the central nervous system. It proposes using the lamprey as a model system due to its ...
KEY FINDING: Functional genomics can be used to elucidate gene regulatory networks (GRNs) in developing tissues, which, like regeneration, are complex systems, therefore, can also be applied to study the molecular mechanisms underlying the complex functions of regeneration.
Cells, 2021 • September 5, 2021
Human iPSCs have become a powerful tool in basic as well as translational and clinical research because of their ability to be maintained indefinitely whilst preserving the genetic makeup of the host. ...
KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).
npj Regenerative Medicine, 2022 • January 1, 2022
This review summarizes the role of the Hippo pathway in zebrafish regeneration, noting that Yap1/Taz signaling often enhances regeneration through promoting cell proliferation, progenitor cell dediffer...
KEY FINDING: Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration, suggesting therapeutic potential in promoting YAP/TAZ signaling to enhance mammalian regeneration.
Exp Neurol, 2010 • May 1, 2010
This study introduces an in vitro model of adult mammalian nerve repair, combining spinal cord slices with peripheral nerve grafts. The model allows for real-time imaging of axon regeneration and prec...
KEY FINDING: Adult nerve grafts remain viable in the co-culture system, maintaining their structure and function, as evidenced by Schwann cell morphology and growth factor expression.
Cell Stem Cell, 2016 • January 7, 2016
The study establishes optogenetic control in human PSC-derived spinal motorneurons and demonstrates functional connectivity with human skeletal muscle. The resulting neuromuscular junction can be trig...
KEY FINDING: Optogenetic stimulation produced calcium spikes in myofibers, which could be blocked by vecuronium.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • June 21, 2013
This study aimed to understand how HMGB1, a protein known to mediate inflammation in mammalian spinal cord injuries, functions in animals capable of spontaneous spinal cord regeneration, specifically ...
KEY FINDING: Gecko HMGB1 paralogs (gHMGB1a and gHMGB1b) exhibit differential responses to spinal cord trauma and inflammatory challenges, with gHMGB1b significantly upregulated in the injured cord.
SMALL GTPASES, 2020 • January 1, 2020
Adult CNS axons fail to regenerate after injury due to extrinsic inhibitory factors and a low intrinsic capacity for axon growth, unlike developing neurons. ARF6 and Rab11, small GTPases, regulate pol...
KEY FINDING: ARF6 activation prevents the axonal transport of integrins in Rab11 endosomes in mature CNS axons, restricting them to the somato-dendritic domain.
Neural Regeneration Research, 2014 • December 1, 2014
This study examined the effects of oral intake of thermomineral water on nerve regeneration in a mouse model of spinal cord injury. The results indicate that thermomineral water promotes locomotor rec...
KEY FINDING: Mice drinking thermomineral water showed significantly better locomotor recovery at 4, 8, and 12 weeks post-injury compared to the control group.
Dev Dyn, 2010 • November 1, 2010
This paper presents a method for visualizing 3D relationships in intact and regenerating adult newt spinal cords using fluorescent probes and confocal microscopy. The method involves fixation, decalci...
KEY FINDING: PLP with 0.5% PFA fixative provided the best streptavidin probe penetration while preserving cellular morphology.