Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 91-100 of 2,298 results
BMC Developmental Biology, 2012 • August 25, 2012
This study investigates positional information during zebrafish caudal fin regeneration by examining bony ray bifurcations after repeated amputations at different locations. The results show that repe...
KEY FINDING: Repeated amputations performed at a long distance from the bifurcation do not change its proximal-distal position in the regenerated fin, while consecutive amputations near the bifurcation induce a positional reset and progressively shift its position distally.
Biomaterials, 2014 • May 1, 2014
The study identifies PTEN antagonist peptides (PAPs) that selectively block PTEN, a negative regulator of axon growth, by targeting its critical functional domains. Systemic administration of PAPs aft...
KEY FINDING: Systemic administration of PTEN antagonist peptides (PAPs) stimulated the growth of descending serotonergic fibers in the caudal spinal cord of adult mice after dorsal over-hemisection injury.
Anat Rec (Hoboken), 2012 • October 1, 2012
This study investigates the tissue-specific signaling requirements for spinal cord and muscle regeneration in Xenopus tadpoles, focusing on the Wnt and Fgf pathways. The results demonstrate that both ...
KEY FINDING: Both spinal cord and muscle regeneration depend on the Wnt-β-catenin and the Fgf pathways.
JOURNAL OF NEUROTRAUMA, 2013 • February 1, 2013
This study investigated the effects of sialidase and chondroitinase ABC (ChABC), alone and in combination, on recovery from spinal cord contusion injury in rats. The enzymes were infused for 2 weeks t...
KEY FINDING: Sialidase treatment alone resulted in significantly increased hindlimb motor function, evidenced by higher BBB scores and fewer stepping errors.
PLoS ONE, 2012 • August 28, 2012
This study investigates the efficacy of acellular sciatic nerve (ASN) combined with brain-derived neurotrophic factor (BDNF) in repairing spinal cord injury (SCI) in adult rats. The results suggest th...
KEY FINDING: Transplantation of ASN-BDNF shows promise for neuron regeneration.
J Neuropathol Exp Neurol, 2012 • October 1, 2012
This study investigated whether transplanting a purified population of embryonic motoneurons into peripheral nerve resulted in more motor units and reinnervation than transplanting a mixed population ...
KEY FINDING: Transplanting more motoneurons did not increase motoneuron survival, and the number of transplanted motoneurons or their survival did not limit muscle reinnervation.
Stem Cells, 2012 • November 1, 2012
This study demonstrates that allogeneic NPCs are rejected following transplantation into the inflamed CNS of JHMV-infected mice due to T cell-mediated immune responses. The research highlights that al...
KEY FINDING: Allogeneic NPCs are antigenic and induce a delayed-type hypersensitivity (DTH) response, indicating T cell involvement.
Cell, 2012 • September 14, 2012
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multi...
KEY FINDING: Neural stem cells, when grafted into sites of complete spinal cord transection, differentiated into neurons and extended axons over remarkably long distances (up to 25 mm) in both rostral and caudal directions.
The Journal of Neuroscience, 2012 • September 19, 2012
The study examined the necessity of continuous NT-3 delivery for sustaining regenerated sensory axons in injured spinal cords using a tetracycline-regulated lentiviral gene delivery system in rats. Re...
KEY FINDING: Regenerated sensory axons require continuous NT-3 delivery for sustained growth and survival in the injured spinal cord.
Exp Neurol, 2013 • January 1, 2013
The study investigated whether exogenous BDNF could enhance axonal regeneration beyond a ChABC-treated glial interface in a chronic spinal cord injury model using peripheral nerve grafts (PNGs). While...
KEY FINDING: ChABC treatment alone promoted axonal regeneration beyond the graft-host interface.