Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,161-2,170 of 2,298 results
Glia, 2007 • May 1, 2007
This study examined the role of Myt1, a transcription factor, in oligodendrocyte regeneration and remyelination in both rodent and human CNS demyelinated lesions. The MHV model was used to induce spin...
KEY FINDING: The density of Myt1 expressing cells markedly increased in lesioned areas of spinal cord white matter in MHV-infected mice, peaking during early remyelination.
PNAS, 2007 • March 13, 2007
The study identifies pleiotrophin (PTN) as a neurotrophic factor upregulated in denervated distal nerve and muscle. Exogenous PTN enhances axonal regeneration and protects facial motor neurons from tr...
KEY FINDING: PTN mRNA is upregulated in denervated Schwann cells and muscle after axotomy, peaking at 7 days and returning to baseline by 3 months.
Neurosci Lett., 2007 • May 11, 2007
The study investigates the role of EphA4 receptor upregulation after spinal cord injury (SCI) in rats, examining its impact on axonal regeneration and nerve conduction. The researchers found that whil...
KEY FINDING: EphA4 protein levels initially decreased after SCI (2 and 4 DPI) and then increased at 7 DPI, with a tendency to further increase at 14 and 28 days.
The Journal of Neuroscience, 2007 • April 11, 2007
This study identifies that the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen and indomethacin overcome neuronal growth inhibitions from CNS myelin and CSPGs via repressing the activity of in...
KEY FINDING: Ibuprofen and indomethacin reverse RhoA activation induced by CNS myelin, CSPGs, or spinal cord lesion.
J Comp Neurol, 2007 • June 20, 2007
This study demonstrates that proximally axotomized spinal interneurons have the potential to form new connections via de novo axons from distal dendrites. A second set of CINs that were proximally axo...
KEY FINDING: Nearly half of the spinal commissural interneurons (CINs) had de novo axons that emerged from distal dendrites after axotomy.
BMC Developmental Biology, 2007 • May 24, 2007
This study investigates the regeneration of neural crest derivatives, specifically melanophores and spinal ganglia, in the Xenopus tadpole tail after amputation. The findings indicate that melanophore...
KEY FINDING: Cells do not emigrate from the spinal cord during tail regeneration, indicating that a new neural crest is not induced as in embryonic development.
The Journal of Neuroscience, 2007 • May 30, 2007
The study investigates targeting regenerating sensory axons to normal synaptic locations in the spinal cord by combining positive and negative guidance molecules. NGF and semaphorin 3A treatment also ...
KEY FINDING: NGF overexpression leads to robust regeneration and sprouting of CGRP-positive nociceptive axons throughout the dorsal and ventral horns.
The Journal of Neuroscience, 2007 • June 13, 2007
This study investigates the effects of inhibiting the epidermal growth factor receptor (EGFR) on recovery from spinal cord injury (SCI) in rats. The researchers used PD168393, a potent EGFR inhibitor,...
KEY FINDING: Treatment with PD168393, an EGFR inhibitor, significantly improved locomotor recovery, as indicated by higher BBB scores and BBB subscores compared to the control group.
Exp Neurol, 2007 • August 1, 2007
The study investigates the physiological properties of regenerated sensory axons in the dorsal columns after spinal cord injury (SCI) in rats. It was found that regenerated axons, six months post-inju...
KEY FINDING: Regenerated axons had reduced conduction velocity compared to intact axons.
Radiation Oncology, 2007 • June 30, 2007
The review summarizes experimental strategies for preventing and treating radiation-induced CNS toxicity, including neurocognitive decline and radiation necrosis, highlighting the importance of tailor...
KEY FINDING: Early intervention with agents like amifostine and growth factors (IGF-1, FGF-2) shows preliminary evidence of modulating the radiation response in the CNS and increasing long-term radiation tolerance.