Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,171-2,180 of 2,298 results
Prog Brain Res, 2007 • January 1, 2007
This review focuses on transplantation studies using olfactory ensheathing cells (OEC) to improve functional outcome in experimental models of SCI and demyelination. Experimental work indicates that c...
KEY FINDING: Transplanted OECs can integrate into the injury site of a dorsal funiculus transection, distribute, associate longitudinally with axons spanning the lesion site, and form myelin.
The Journal of Neuroscience, 2007 • July 25, 2007
This study investigates the role of ATF3, a transcription factor induced by peripheral nerve injury, in promoting nerve regeneration. The researchers generated transgenic mice that constitutively expr...
KEY FINDING: ATF3 enhances the rate of peripheral nerve regeneration to an extent comparable to a preconditioning nerve injury.
Exp Neurol, 2008 • February 1, 2008
The failure of axons to regenerate after spinal cord injury remains a significant challenge, but advances have been made in identifying inhibitory proteins in CNS myelin. Elevation of intracellular cA...
KEY FINDING: Elevation of intracellular cAMP levels promotes axonal regeneration in the CNS, overcoming myelin inhibition both in vitro and in vivo.
Cell Mol Neurobiol, 2007 • September 19, 2007
The study investigates changes in cAMP levels in the developing opossum spinal cord during the critical period when regeneration stops being possible. Endogenous cAMP levels were measured in tissue ho...
KEY FINDING: A significant decrease in cAMP levels was observed during the period when the opossum spinal cord loses its regenerative capability.
BMC Neuroscience, 2007 • September 27, 2007
The study investigated axonal regeneration in NG2 knockout mice compared to wild-type controls after injuries to the CNS (corticospinal tract, dorsal column, dorsal root) and PNS (sciatic and facial n...
KEY FINDING: NG2 deficiency did not enhance regeneration of corticospinal tract axons after spinal cord injury.
Exp Neurol, 2008 • February 1, 2008
The review discusses the progress in understanding the mechanisms behind successful axonal regeneration in the peripheral nervous system and the failure of regeneration in the central nervous system. ...
KEY FINDING: Adult axons retain sensitivity to growth factors, and patterns of growth factor sensitivity after injury in adulthood recapitulate developmental patterns.
Cellular and Molecular Life Sciences, 2008 • November 3, 2007
Investigations into mechanisms that restrict the recovery of functions after an injury to the brain or the spinal cord have led to the discovery of specific neurite growth inhibitory factors in the ad...
KEY FINDING: Neutralizing Nogo-A promotes axonal regeneration of various types of CNS neurons.
Cell. Mol. Life Sci., 2008 • November 20, 2007
Significant spinal cord regeneration following injury is not observed in any adult higher vertebrates (amniotes), but can occur in some lower vertebrates (anamniotes) such as tailed amphibians and fis...
KEY FINDING: Clearwaters reported regeneration in the embryonic spinal cord, but lack of regeneration and extensive scarring in the postnatal spinal cord.
PNAS, 2007 • December 4, 2007
This study examined the impact of functional electrical stimulation (FES) on denervated muscles in spinal cord injury patients. The patients underwent FES for 2.4-9.3 years. Results showed significant...
KEY FINDING: FES treatment significantly increased muscle fiber diameter in denervated muscles compared to untreated muscles. The fiber size increase was accompanied by a reduction in connective and adipose tissues.
PLoS ONE, 2007 • November 28, 2007
This study investigates the role of TGF-b signaling in axolotl limb regeneration, highlighting the contrast with TGF-b's role in mammalian wound healing, which often results in scarring. The researche...
KEY FINDING: The full-length cDNA sequence of axolotl TGF-b1 was isolated, revealing high homology with mammalian TGF-b1 sequences.