Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,241-2,250 of 2,298 results
The Journal of Neuroscience, 2009 • August 12, 2009
This study investigates how to prevent macrophage-induced retraction of dystrophic adult sensory neurons after CNS injury, using an in vitro model of the glial scar. The researchers found that proteas...
KEY FINDING: General inhibition of matrix metalloproteinases and specific inhibition of MMP-9 prevented macrophage-induced axonal retraction.
Exp Neurol, 2010 • May 1, 2010
This study demonstrates that overexpression of NGF distal to a nerve bifurcation enhances the accuracy of sensory axon reinnervation following nerve transection in a rat femoral nerve model. The enhan...
KEY FINDING: NGF overexpression significantly increased the accuracy of saphenous branch axon reinnervation to the appropriate nerve branch.
Respir Physiol Neurobiol, 2009 • November 30, 2009
This review highlights current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury. Restoration of respiratory function will be a critical applicati...
KEY FINDING: Axonal growth is supported by inherent properties of the selected polymer, the architecture of the scaffold, permissive microstructures such as pores, grooves or polymer fibres, and surface modifications to provide improved adherence and growth directionality.
J Neurosci Res, 2010 • February 1, 2010
This study investigates the effect of immediate anti-TNF-α (etanercept) therapy on nerve regeneration after sciatic nerve crush injury in rats. The researchers found that TNF-α mRNA expression increas...
KEY FINDING: TNF-α mRNA expression is induced at 1 day and returned to baseline at 5 days after injury in nerve and the corresponding dorsal root ganglia (DRG).
Molecular Therapy, 2010 • January 1, 2010
This study investigated the potential of PSA and HNK-1 mimetics to promote regeneration and functional recovery after spinal cord injury in mice. The mimetics were delivered via subdural infusions usi...
KEY FINDING: Treatment with PSA mimetic, alone or in combination with HNK-1 mimetic, improved functional outcome of compression spinal cord injury compared with the control treatment.
J. Cell. Mol. Med., 2011 • February 1, 2011
The study investigates the de-differentiation potential of murine glomerular epithelial cells in vitro, focusing on the role of EMT in imparting plasticity to GPECs. Results demonstrate that GPECs of ...
KEY FINDING: GPECs from adult murine kidneys can undergo EMT in vitro, leading to the generation of cells expressing CD24, CD44, and CD29 surface antigens.
Clin Exp Pharmacol Physiol, 2010 • April 1, 2010
Glypican-1 is a major high-affinity ligand of the Slit proteins. Slit-2 and glypican-1 mRNA are upregulated and coexpressed in reactive astrocytes of injured adult brain, suggesting their involvement ...
KEY FINDING: Several potent inhibitors of glypican–Slit interactions were identified, including a low molecular weight periodate-oxidized heparin with no significant anticoagulant activity.
Curr Opin Organ Transplant, 2010 • February 1, 2010
iPS cells hold great promise due to their potential to circumvent ethical and immunological challenges associated with ES cells. However, their use is limited by reprogramming efficiency and therapeut...
KEY FINDING: Somatic cells can be reprogrammed to a pluripotent state using retroviral transduction of only 4 genes: Sox2, Oct4/Pou5f1, c-Myc, and Klf4. These are termed the “Yamanaka factors”.
Nat Neurosci, 2009 • November 1, 2009
The study demonstrates that Mst3b mediates the effects of trophic factors in stimulating axon outgrowth in adult RGCs and DRG neurons. Mst3b exerts its effects through changes in its kinase activity. ...
KEY FINDING: Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons.
Neuron, 2009 • October 29, 2009
This study demonstrates that bridging axonal regeneration can be achieved in the adult CNS even when treatments are initiated at extended delays after spinal cord injury (SCI). Effective regeneration ...
KEY FINDING: Combinatorial therapies (peripheral nerve conditioning lesions, grafts of marrow stromal cells, and NT-3 gradients) promote axonal regeneration into and beyond a mid-cervical lesion site, even when administered 6 weeks to 15 months after SCI.