Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,281-2,290 of 2,298 results
Indian J Orthop, 2010 • July 1, 2010
This experimental study investigates the regenerative cell proliferation effects of bone marrow supplemented with neurotransmitters combinations in the regeneration of spinal cord injury The monoplegi...
KEY FINDING: The monoplegia in the test group of rats recovered significantly (P value < 0.01) with supplementation of the bone marrow cells and neurotransmitters combination.
The Journal of Neuroscience, 2010 • August 11, 2010
This study investigates the potential of genetically attenuating myelin and Semaphorin-mediated inhibition to promote axon regeneration after spinal cord injury. The research focused on serotonergic a...
KEY FINDING: Deleting Nogo, MAG, and NgR1 (three myelin inhibitors) did not enhance serotonergic axon regeneration after complete spinal cord transection.
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010 • August 14, 2010
The study cloned GFAP cDNA from Gekko japonicus and examined its expression changes after spinal cord transection. GFAP expression increased and then decreased after spinal cord injury (SCI), predomin...
KEY FINDING: GFAP expression in the spinal cord increased after transection, peaking at 3 days, then gradually decreasing.
The Journal of Clinical Investigation, 2010 • September 1, 2010
This commentary discusses a study by Abematsu et al. on neural stem cell transplantation in a mouse model of spinal cord injury (SCI). The study demonstrates that transplanted neural stem cells, when ...
KEY FINDING: Neural stem cell transplantation can reconstruct spinal neuronal circuits in mice with severe spinal cord injury.
The Journal of Neuroscience, 2010 • August 25, 2010
This study challenges the long-standing controversy about whether spinal cord injury (SCI) causes retrograde cell death of corticospinal tract (CST) neurons. By directly assessing CST axons in the med...
KEY FINDING: Only a small fraction of axons in the medullary pyramid showed signs of degeneration after SCI, comparable to uninjured rats.
J Neurosci Res, 2010 • November 1, 2010
This study demonstrates that injection of IKVAV-PA into the injured spinal cord consistently improves behavioral outcome in both rats and mice with different spinal cord injury models. The major poten...
KEY FINDING: IKVAV PA injection leads to a significantly higher density of serotonergic fibers caudal to the injury site in the chronically injured spinal cord.
Dev Dyn, 2010 • November 1, 2010
This paper presents a method for visualizing 3D relationships in intact and regenerating adult newt spinal cords using fluorescent probes and confocal microscopy. The method involves fixation, decalci...
KEY FINDING: PLP with 0.5% PFA fixative provided the best streptavidin probe penetration while preserving cellular morphology.
Dev Neurobiol, 2011 • July 1, 2011
This study investigates the expression and activation of ephexin after spinal cord injury (SCI) in rats. Ephexin, a guanine nucleotide exchange factor, is involved in Eph signaling pathways that can m...
KEY FINDING: Ephexin protein expression increases after SCI, peaking at 4-7 days post-injury and returning to normal levels by 14 days.
Journal of Inflammation, 2010 • October 25, 2010
This study investigates the in vivo immuno-regulatory effectiveness of human mesenchymal stem cells (hMSCs) using an ovalbumin challenge model of acute asthma in mice. The results demonstrate a direct...
KEY FINDING: hMSCs are well tolerated in the murine model of acute asthma, suggesting that hMSCs can favorably change the outcome of asthmatic inflammation without the pathology associated with cross-species application.
Journal of Biological Chemistry, 2011 • January 21, 2011
This study investigates the role of Paired Immunoglobulin-like Receptor B (PIR-B) in axonal regeneration after spinal cord injury (SCI) using PIR-B-knock-out mice. The researchers found that deleting ...
KEY FINDING: Hindlimb motor function, assessed using various tests, did not significantly differ between PIR-B-knock-out and wild-type mice after dorsal hemisection of the spinal cord.