Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,271-2,280 of 2,298 results
Neuron, 2010 • June 10, 2010
The study investigates the role of myelin inhibitors Nogo, MAG, and OMgp in axon regeneration and sprouting after spinal cord injury using genetically modified mice. Results indicate that deleting any...
KEY FINDING: Deleting any one of the inhibitors (Nogo, MAG, or OMgp) enhanced sprouting of corticospinal or raphespinal serotonergic axons.
Nat Rev Neurol, 2010 • July 1, 2010
Stem cell therapy holds promise for treating spinal cord injury (SCI) by potentially replacing damaged cells, providing trophic support, and facilitating axon regeneration. While stem cell transplanta...
KEY FINDING: Stem cell transplantation strategies for SCI include replacing lost or damaged cells (neurons and oligodendrocytes), providing trophic support, and manipulating the environment to facilitate axon regeneration.
Brain Res Bull, 2011 • March 10, 2011
The adult mammalian central nervous system (CNS) faces challenges in recovering from neurotrauma and disease due to axon disruption, neuronal death, target denervation, and functional deficits. Constr...
KEY FINDING: Neurotrophins alone can induce regeneration of sensory axons, but they may not terminate in appropriate target regions without additional guidance signals.
Exp Neurol, 2010 • September 1, 2010
This study investigated the use of peripheral nerve grafts (PNG) combined with chondroitinase ABC (ChABC) to promote axon regeneration after incomplete cervical spinal cord injury (SCI) in adult cats....
KEY FINDING: The peripheral nerve grafts survived in most animals, and thousands of myelinated axons were found within each graft.
Molecular Therapy, 2010 • October 1, 2010
The study investigates the role of tenascin-C (TNC) in spinal cord regeneration using TNC-deficient mice and wild-type controls after spinal cord injury. The findings indicate that TNC deficiency impa...
KEY FINDING: TNC-deficient mice exhibit impaired locomotor recovery after spinal cord injury compared to wild-type mice.
PNAS, 2010 • July 13, 2010
This study investigates the therapeutic potential of induced pluripotent stem (iPS) cells for spinal cord injury (SCI) treatment in mice, emphasizing the importance of pre-evaluating iPS cell safety. ...
KEY FINDING: Pre-evaluated safe iPS cells can differentiate into functional neurons, astrocytes, and oligodendrocytes in vitro.
J Pain, 2010 • November 1, 2010
This study demonstrates that skin incision, even without direct nerve injury, induces the expression of axonal regeneration-related genes in adult rat spinal sensory neurons. The researchers observed ...
KEY FINDING: Skin incision led to a significant increase in ATF3 expression in DRG neurons.
STEM CELLS, 2010 • July 27, 2010
This study evaluated the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult ...
KEY FINDING: Transplanted OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons within the injured spinal cord.
PLoS ONE, 2010 • July 29, 2010
This study investigates the potential of human motor neuron progenitors (hMNPs), derived from human embryonic stem cells (hESCs), to treat spinal cord injury (SCI) in rats. The research demonstrates t...
KEY FINDING: hMNP transplantation suppresses SCI pathogenesis-related signaling pathways, which correlates with enhanced endogenous neuronal survival and neurite branching.
Nat Neurosci, 2010 • September 1, 2010
This study investigates the role of PTEN/mTOR in controlling the regenerative capacity of mouse corticospinal neurons after spinal cord injury. The researchers found that forced up-regulation of mTOR ...
KEY FINDING: Deleting PTEN in adult corticospinal neurons enhances compensatory sprouting of uninjured CST axons.