Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 21-30 of 2,298 results
J. R. Soc. Interface, 2011 • April 27, 2011
This study introduces a novel application of genipin-cross-linked casein (GCC) to fabricate biodegradable conduits for peripheral nerve repair, capitalizing on the biocompatibility and non-toxicity of...
KEY FINDING: GCC conduits are non-toxic and support Schwann cell survival and outgrowth, essential for nerve regeneration.
Acta Biomater, 2011 • July 1, 2011
This study developed electrically conductive nanowire surfaces using PCL coated with PPy to enhance neural stem cell (NSC) adhesion, proliferation, and differentiation, addressing the need for improve...
KEY FINDING: Polypyrrole (PPy) coating significantly reduces the electrical resistivity of PCL nanowires, creating a functional surface for electrical stimulation.
Cell Tissue Res., 2011 • June 1, 2011
This study investigates the cellular mechanisms of spinal cord regeneration in fresh-water turtles, focusing on cell proliferation and cytoarchitectural changes following injury. The research demonstr...
KEY FINDING: Spinal cord transection induces a significant increase in cell proliferation around the lesion epicenter in turtles.
Stem Cells and Cloning: Advances and Applications, 2012 • September 24, 2012
Stem cell transplantation offers potential for restoring function and easing the burden associated with spinal cord injury (SCI). The most convincing results have been obtained with neural progenitor ...
KEY FINDING: Neural progenitor cells have yielded the most promising outcomes in preclinical models of SCI treatment.
Frontiers in Neurology, 2011 • April 27, 2011
This study compared nerve repair using ethyl cyanoacrylate (ECA) adhesive versus conventional sutures in rats after sciatic nerve transection, focusing on the selectivity of reinnervation of the later...
KEY FINDING: The study found that after nerve repair with both ECA and sutures, the motoneuron pool was markedly disorganized, with motoneurons scattered throughout a larger volume of the spinal cord gray matter.
Exp Neurol, 2012 • May 1, 2012
Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research to promote axonal repair after spinal cord injury. Different definitions of axon sp...
KEY FINDING: Genetic analysis using Nogo knockout mice produced different outcomes ranging from robust, suggestive, to no regeneration, which have led to a major controversy regarding Nogo’s role in axon regeneration.
PLoS ONE, 2011 • May 18, 2011
This study evaluated the neurorigenerative properties of RADA16-4G-BMHP1 SAP by injecting the scaffold immediately after contusion in the rat spinal cord, then evaluating the early effects by semi-qua...
KEY FINDING: The functionalized SAP, RADA16-4G-BMHP1, induced a general upregulation of GAP-43, trophic factors and ECM remodelling proteins at 7 days after lesion.
Frontiers in Neurology, 2011 • May 17, 2011
This study investigates the expression of Activating Transcription Factor 3 (ATF3) after nerve injuries in rats and humans, aiming to determine if ATF3 induction correlates with regenerative response ...
KEY FINDING: ATF3 expression is up-regulated in a distance-dependent manner after nerve lesions. The closer the lesion is to the cell body, the earlier ATF3 is detected.
Cell Mol Neurobiol, 2011 • June 1, 2011
This study investigates the effect of ChABC on axon regeneration after spinal cord injury in rats. The researchers found that ChABC treatment decreased NG2 expression and enhanced GAP-43 expression at...
KEY FINDING: Multiple injections of ChABC decreased NG2 expression at the lesion site at 5 and 7 days after injury compared to vehicle-treated rats.
Biomaterials, 2011 • September 1, 2011
This study investigates the use of aligned poly-L-lactic acid (PLA) microfibers to promote axonal regeneration after complete spinal cord transection in rats. The researchers found that aligned microf...
KEY FINDING: Aligned poly-L-lactic acid (PLA) microfibers promote long-distance axonal regeneration in a rat model of complete spinal cord transection.