Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 551-560 of 607 results
Heliyon, 2019 • March 4, 2019
This review provides a comprehensive overview of experimental SCI rat models and commonly used behavioral tests for assessing recovery. It highlights the advantages and disadvantages of different inju...
KEY FINDING: The review highlights three main SCI rat models: compression, contusion, and transection, each mimicking different aspects of human SCI and having specific advantages and limitations for research.
Top Spinal Cord Inj Rehabil, 2018 • January 1, 2018
This study investigated racial/ethnic differences in response completeness within a longitudinal spinal cord injury (SCI) database, including 7,507 participants. The study found that missing data rate...
KEY FINDING: The overall missing data rate was significant across several measures, including economic self-sufficiency, alcohol use, drug use, life satisfaction, depression, and pain severity.
ZEBRAFISH, 2024 • April 1, 2024
This study examines the effects of different diets on the growth and spinal cord regeneration of larval zebrafish. Three diets were compared: live rotifers, a commercial powder diet, and nutritive med...
KEY FINDING: Larvae fed a live rotifer diet grew 32% in length, while those fed a commercial diet only grew 4%.
Neural Regeneration Research, 2016 • June 1, 2016
This study aimed to improve animal models of chronic thoracolumbar cord compression using a progressive screw method. A custom-designed flat plastic screw was implanted in the spinal cord between thor...
KEY FINDING: Progressive screw compression successfully induced chronic thoracolumbar spinal cord injury in rats, as evidenced by motor function decline and stenosis.
Neural Regen Res, 2019 • April 1, 2019
This study aimed to establish and verify a surgical prognostic model for cervical spinal cord injury without radiological abnormality. The model uses factors like cervical stenosis, JOA score, and dis...
KEY FINDING: A prognostic model was established: logit(P) = −25.4545 + 21.2576VALUE + 1.2160SCORE − 3.4224TIME, where VALUE is the Pavlov ratio, SCORE is the JOA score, and TIME is disease duration.
Bio-protocol, 2017 • June 20, 2017
This study outlines a detailed protocol for establishing a contusion spinal cord injury (SCI) model in adult rats, utilizing the NYU-MASCIS weight-drop impactor. The method aims to replicate the commo...
KEY FINDING: The study details the surgical procedure for creating a reproducible contusion SCI model in rats using the NYU-MASCIS impactor.
Neurological Research and Practice, 2019 • April 4, 2019
This study demonstrates a positive correlation between ulnar nerve CMAP amplitudes and AIS incompleteness over time in cervical SCI patients. Early ulnar nerve axonal integrity (within 4 weeks) is an ...
KEY FINDING: Higher ulnar nerve CMAP amplitudes are associated with better AIS grades over the entire follow-up period in cervical SCI patients.
PLoS ONE, 2019 • November 22, 2019
This study analyzes the relationship between journal size and the longitudinal variability of the Journal Impact Factor (JIF) using a comprehensive dataset of journals from the Incite Journal Citation...
KEY FINDING: Larger journals generally exhibit smaller annual changes in their Journal Impact Factor (JIF) compared to smaller journals, indicating greater stability.
Brain, 2020 • May 6, 2020
This study investigated the safety and efficacy of NgR1-Fc (AXER-204), a Nogo receptor decoy, in treating spinal cord injury in non-human primates. The results indicated that NgR1-Fc is safe for admin...
KEY FINDING: NgR1-Fc (AXER-204) administration showed no preclinical toxicological issues in healthy animals or safety concerns in spinal cord injury animals.
Health and Quality of Life Outcomes, 2013 • October 18, 2013
The study aimed to disentangle scale recalibration from anticipated adaptation in patients with spinal cord injury (SCI) by comparing their predicted, recalled, and actual quality of life (QoL) rating...
KEY FINDING: Patients with SCI accurately predicted their future health states and recalled their previous health states using the TTO method.