Research Methodology & Design Research
Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 71-80 of 702 results
Ameliorative potential of stem cells from human exfoliated deciduous teeth (SHED) in preclinical studies: A meta-analysis
Regenerative Therapy, 2023 • June 7, 2023
This meta-analysis evaluates the therapeutic potential of stem cells from human exfoliated deciduous teeth (SHED) in preclinical animal models across various diseases. The study found statistically si...
KEY FINDING: SHED intervention in several diseases depicted statistically significant therapeutic effects in periodontitis, pulpitis, spinal cord injury, parkinson's disease, alzheimer's disease, focal cerebral ischemia, peripheral nerve injury, and retinal pigmentosa.
Efficacy and Safety of Conservative Treatment Compared With Surgical Treatment for Thoracolumbar Fracture With Score 4 Thoracolumbar Injury Classification and Severity (TLICS) A Systematic Review and Meta-analysis
Clin Spine Surg, 2024 • June 1, 2024
This meta-analysis compared surgical and conservative treatments for thoracolumbar fractures with a TLICS score of 4. The study found that surgical treatment may offer benefits in terms of faster retu...
KEY FINDING: Surgical treatment resulted in a shorter length of returning to work compared to nonsurgical treatment.
A novel mouse model of central cord syndrome
Neural Regeneration Research, 2023 • April 20, 2023
This study successfully established a novel mouse model of central cord syndrome (CCS) by applying controlled blunt trauma to the C6 spinal cord. Behavioral, histological, and MRI analyses confirmed t...
KEY FINDING: The mouse model of CCS exhibited impaired motor function in the front paws while retaining basic motor and sensory functions of the lower extremities, mirroring the symptoms of human CCS.
Acute penetrating injury of the spinal cord by a wooden spike with delayed surgery: a case report
Neural Regeneration Research, 2023 • April 10, 2023
This case report details the management of a 23-year-old man with a penetrating cervical spinal cord injury from a wooden stick. The patient initially presented with tetraparesis but rapidly recovered...
KEY FINDING: Penetrating spinal cord injuries from wooden objects carry a high risk of infection.
Development of a Sham Protocol to Investigate Transcutaneous Tibial Nerve Stimulation in Randomised, Sham-Controlled, Double-Blind Clinical Trials
Biomedicines, 2023 • July 7, 2023
This study developed an optimal sham configuration for transcutaneous tibial nerve stimulation (TTNS) to be used in randomized controlled trials (RCTs). The researchers tested three potential electrod...
KEY FINDING: The 5th metatarsal position with 3.2 cm electrodes was found to be the most suitable sham configuration, achieving a 100% motor response rate.
Exceptional Spinal Mobility Caused by Charcot Disease: Case Description with Several Years of Follow‑Up
Indian Journal of Orthopaedics, 2023 • July 1, 2023
This case report describes a unique complication of Charcot Spinal Arthropathy (CSA) in a patient with a post-traumatic spinal cord injury, highlighting the replacement of vertebral structures with fi...
KEY FINDING: The patient exhibited exceptional spinal movement in the coronal and sagittal planes due to the replacement of the discal space and vertebral bodies with fibrotic tissue.
Efficacy of surgical treatment and conservative treatment for cervical spinal cord injury without fracture and dislocation in adults: A meta-analysis
Medicine, 2023 • August 2, 2023
This meta-analysis aimed to determine the superior treatment method between surgical and conservative approaches for adult patients with Cervical Spinal Cord Injury Without Fracture and Dislocation (C...
KEY FINDING: Surgical treatment showed a significantly higher effective rate compared to conservative treatment (OR = 4.737, P < .001).
Difficult tracheostomy decannulation related to nasogastric tube syndrome: A case report
International Journal of Surgery Case Reports, 2023 • August 31, 2023
This case report describes a 65-year-old woman who developed difficult tracheostomy decannulation due to upper airway obstruction, which was attributed to nasogastric tube syndrome (NGTS). The patient...
KEY FINDING: The patient experienced severe inspiratory difficulty and supraglottic swelling, completely covering the opening of the glottis, when tracheostomy decannulation was attempted.
Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
Neural Regen Res, 2024 • July 20, 2023
This systematic review analyzes 22 animal studies on distraction spinal cord injury (DSCI), focusing on neurophysiological, histological, and behavioral characteristics. The review identifies that the...
KEY FINDING: DSCI severity, assessed through neurophysiology, histology, and behavior, increases with the degree and duration of distraction, highlighting the importance of these factors in injury progression.
Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies
Korean J Pain, 2023 • August 1, 2023
This systematic review and meta-analysis evaluated the efficacy of muscimol in ameliorating nerve injury-related neuropathic pain based on preclinical studies. The study found that muscimol is effecti...
KEY FINDING: Muscimol significantly reduces mechanical allodynia (SMD = 1.78 [1.45–2.11]; P < 0.0001; I2 = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28–1.96]; P < 0.0001; I2 = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79–3.39]; P < 0.0001; I2 = 80.33%).