Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,541-7,550 of 7,662 results
Neural Regeneration Research, 2015 • December 1, 2015
TMS studies show increased motor cortex excitability after SCI, likely as a compensatory mechanism for impaired motor function. Various TMS techniques, such as SICI, MEP recruitment curves, and I-wave...
KEY FINDING: Motor cortex excitability is increased after spinal cord injury, as indicated by TMS studies. This suggests the brain attempts to compensate for impaired motor function.
Molecular Medicine Reports, 2020 • July 6, 2020
This study investigates the potential of using neural stem cells (NSCs) preconditioned with high mobility group box-1 (HMGB1) to improve functional recovery after spinal cord injury (SCI) in rats. The...
KEY FINDING: Transplantation of NSCs preconditioned with 1 ng/ml HMGB1 facilitated functional improvement of injured spinal cords, as indicated by improved Basso, Beattie and Bresnahan mean scores, reduced mechanical hypersensitivity, and decreased cold stimulation response.
The Journal of Spinal Cord Medicine, 2018 • July 1, 2018
The study examined the effect of level of spinal cord injury (LOI) on adipose tissue, proinflammatory adipokines, and cardiometabolic profiles in individuals with motor complete SCI. Results indicated...
KEY FINDING: The study found that the level of injury did not significantly influence the distribution of adipose tissue.
J. Exp. Med., 2019 • November 4, 2019
This study investigates how neuronal circuits remodel after spinal cord injury, focusing on the role of neuronal activity in target selection during corticospinal tract (CST) rewiring. The researchers...
KEY FINDING: NMDAR signaling and CREB-mediated transcription are essential for maintaining nascent corticospinal tract (CST)–relay neuron contacts during circuit remodeling after spinal cord injury.
Top Spinal Cord Inj Rehabil, 2014 • January 1, 2014
This study investigates the employment participation of Canadians with SCI from a life course perspective, comparing young/middle-aged and older adults. It considers demographic, health, and social fa...
KEY FINDING: Close to one-third of participants with SCI were working post injury (32%), a decline from the 62% of respondents working prior to their injury.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This study investigated the association between seeking oral health information online and oral health knowledge and behaviors among adults with spinal cord injury (SCI). The study found a significant...
KEY FINDING: About 12% of the respondents searched oral health information online in the past 12 months.
Clin Neurophysiol, 2014 • October 1, 2014
Persons with iSCI have fewer “building blocks” for constructing muscle activity, limiting the complexity of muscle coordination for overground walking. iSCI modules cannot explain the diversity of mus...
KEY FINDING: Motor module number, composition, and activation were significantly altered in persons with iSCI as compared to AB controls during overground walking at self-selected cadences.
Ann Transl Med, 2021 • July 1, 2021
This study investigated the effects of GelMA hydrogel on nerve repair and regeneration in mice with spinal cord injury (SCI). The results showed that GelMA hydrogel improved exercise ability, lengthen...
KEY FINDING: GelMA hydrogel improved exercise ability in mice with SCI. Mice treated with GelMA hydrogel had markedly higher total scores and sub-scores on the BMS compared to the model group.
CNS Neuroscience & Therapeutics, 2024 • August 5, 2024
This review discusses the efficacy of targeted therapy in enhancing myelin repair after SCI by identifying key molecules and signaling pathways. This review demonstrates challenges and future perspect...
KEY FINDING: Targeted therapies show promise in enhancing myelin repair after SCI by modulating key molecules and signaling pathways.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This study investigated the effectiveness of oral vitamin D3 supplementation in individuals with chronic spinal cord injury (SCI) and vitamin D deficiency. The results showed that a daily prescription...
KEY FINDING: Oral vitamin D3 supplementation (2000 IU daily) for 3 months safely raised serum 25(OH)D levels into the normal range in persons with chronic SCI on calcium supplementation.