Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,531-7,540 of 7,812 results
Neural Regeneration Research, 2021 • January 1, 2021
This study investigates the effectiveness of a combined approach using laminin-coated filaments, Schwann cells, and glial cell line-derived neurotrophic factor (GDNF) to promote axonal regeneration in...
KEY FINDING: Channels with filaments significantly reduced the lesion cavity, astrocytic gliosis, and inflammatory responses at the graft-host boundaries.
NeuroReport, 2020 • January 1, 2020
This study investigates the protective effects of Tricholoma matsutake polysaccharides (TMP) on spinal cord injuries (SCIs) both in vitro and in vivo. The results showed that TMP promotes neuronal pro...
KEY FINDING: TMP promoted neurite growth and inhibited the production of TNFα, IL-6, and NF-kappa B in cells treated with hydrogen peroxide.
Frontiers in Cellular Neuroscience, 2020 • August 5, 2020
This review discusses the role of chondroitin sulfate proteoglycans (CSPGs) in the injury response following spinal cord injury, focusing on how sulfated glycosaminoglycan (GAG) chains inhibit plastic...
KEY FINDING: The sulfation patterns of GAG chains on CSPGs influence their biological activity and interactions with potential receptors, impacting axonal regeneration.
Neural Regeneration Research, 2021 • February 1, 2021
Hydrogel-based drug delivery strategies offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associ...
KEY FINDING: Hydrogel pore size can be varied to control drug release, with larger pore sizes leading to faster drug release.
Neural Regen Res, 2021 • August 24, 2020
This retrospective case series evaluated the safety and effectiveness of combined autologous PRP and BMAC administration via intrathecal and intravenous routes in seven SCI patients. The study found t...
KEY FINDING: Intrathecal/intravenous co-administration of PRP and BMAC resulted in no significant complications.
Journal of Neuroinflammation, 2020 • August 25, 2020
Following SCI, neuronal pyroptosis lasted longer and occurred farther away from the injury core compared with that of neuronal apoptosis. Microglial Hv1 deficiency downregulated microglial ROS generat...
KEY FINDING: Neuronal apoptosis peaked earlier than pyroptosis after SCI, but pyroptosis lasted longer.
Journal of Molecular Neuroscience, 2021 • September 8, 2020
This study investigates the effect of microtubule stabilization on microcirculation reconstruction after spinal cord injury (SCI). The results showed that microtubule stabilization promotes angiogenes...
KEY FINDING: Microtubule stabilization promotes microcirculation reconstruction after SCI by increasing the number of microvessels, pericytes, and perfused microvessels.
Nature Communications, 2020 • September 9, 2020
This study presents a pH-responsive immunomodulatory strategy for neural regeneration using electrospun fibers that release IL-4 plasmids to suppress inflammation and promote neural differentiation. T...
KEY FINDING: The microenvironment-responsive immunoregulatory electrospun fibers were able to shift immune cell subtypes to down-regulate the acute inflammation response.
Dose-Response: An International Journal, 2020 • July 1, 2020
The study successfully developed a biofabricated nano-cerium oxide loaded PCL polymer with RVL, characterizing the nanomaterial through various analytical techniques. The CeO2-PCL/RVL bionanomaterials...
KEY FINDING: Nano CeO2 particles assembled onto PCL/RVL were successfully synthesized using a biocompatible ionic liquid.
J Mech Behav Biomed Mater, 2020 • October 1, 2020
This study demonstrates that chronic spinal cord glial scars possess decreased Young’s modulus that propagates outward from the injury core. The most significant features of the chronic scar included ...
KEY FINDING: The chronic spinal cord injury scar has decreased Young’s modulus compared to naïve tissue.