Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,711-7,720 of 7,812 results
The Journal of Neuroscience, 2009 • January 28, 2009
This study demonstrates that the EGF receptor, when activated in astrocytes, triggers a signaling pathway involving Akt, Tuberin, Rheb, and mTOR. The research also shows that this pathway is functiona...
KEY FINDING: EGF activates the mTOR pathway in cultured adult spinal cord astrocytes through Akt-mediated phosphorylation of Tuberin, leading to Rheb activation.
TISSUE ENGINEERING: Part A, 2009 • July 1, 2009
The study investigates the use of biodegradable polymer scaffolds loaded with neural stem cells (NSCs) and Schwann cells (SCs) to promote axonal regeneration in a rat model of complete spinal cord tra...
KEY FINDING: Biodegradable scaffolds seeded with NSCs or SCs facilitate regeneration across the transected spinal cord.
Exp Neurol, 2009 • May 1, 2009
This study investigates the expression of myelin inhibitors Nogo-A and MAG during oligodendrogliogenesis and their effects on neurite outgrowth. The findings reveal that OPCs express Nogo-A but not MA...
KEY FINDING: OPCs express the intracellular domain of Nogo-A but not MAG, while mature oligodendrocytes express both.
Exp Neurol, 2009 • June 1, 2009
This study investigates the expression of RGM and its receptor neogenin in the sea lamprey spinal cord after injury. It aims to understand their roles in axon regeneration, which occurs in lampreys bu...
KEY FINDING: RGM mRNA is expressed in the spinal cord of sea lampreys, primarily in neurons of the lateral gray matter and dorsal cells.
Exp Neurol, 2009 • June 1, 2009
This study presents a straight alley version of the BBB locomotor scale for assessing hindlimb motor function in rats after spinal cord injury. The method involves training rats to ambulate in a rewar...
KEY FINDING: BBB scores in the open field and straight alley were highly correlated (r=0.90), validating the straight alley for locomotor assessment.
PNAS, 2009 • April 28, 2009
The study investigates methods to induce regeneration of corticospinal axons, which are crucial for motor function but typically do not regenerate after injury. The researchers hypothesized that enhan...
KEY FINDING: Overexpression of trkB in layer V motor cortex in vivo induces axonal regeneration after subcortical axotomy.
TISSUE ENGINEERING: Part A, 2009 • November 1, 2009
This study investigates the host response to porous multiple channel bridges implanted in a rat spinal cord hemisection model, focusing on the distribution and organization of cells within the bridge....
KEY FINDING: Multiple channel bridges support cellular infiltration, creating a permissive environment for neural fiber growth.
Acta Biomater., 2009 • September 1, 2009
This study examined the effect of scaffold channel size on axonal regeneration in transected rat spinal cords using Schwann cell-seeded PLGA scaffolds. The study found that smaller diameter channels (...
KEY FINDING: Scaffolds with 450-μm channels had significantly more axon fibers per channel than 660-μm scaffolds at 1 and 3 months post-implantation.
JOURNAL OF NEUROTRAUMA, 2009 • October 1, 2009
The study demonstrates that a biodegradable polymer scaffold loaded with Schwann cells supports axon regeneration after spinal cord transection in rats. Fast Blue retrograde tracing was used to quanti...
KEY FINDING: Axons regenerated bidirectionally through the PLGA scaffolds after cord transection.
Exp Neurol, 2009 • September 1, 2009
This study investigates the conversion of crossed phrenic activity from a spontaneously active to latent status during postnatal development in rats. Crossed phrenic activity was spontaneously express...
KEY FINDING: Crossed phrenic activity is spontaneously expressed in all three parts of the ipsilateral hemidiaphragm of P2 rats following C2 hemisection injury.