Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,721-7,730 of 7,812 results
J Comp Neurol, 2009 • July 10, 2009
This study demonstrates that fresh-water turtles can reconnect their completely transected spinal cord leading to some degree of recovery of the motor functions lost after injury. The reconnection inv...
KEY FINDING: Some turtles regained the ability to perform stepping locomotion after spinal cord transection, although slower than normal.
Cell Mol Neurobiol, 2009 • June 17, 2009
This study compared the effects of undifferentiated and differentiated adipose tissue-derived stromal cells (ADSCs) on functional recovery after spinal cord injury (SCI) in rats. ADSCs were differenti...
KEY FINDING: Transplantation of uADSCs, dADSC-P1, and dADSC-P2 all significantly improved locomotor functional recovery in SCI rats compared to saline-treated controls.
Neurotherapeutics, 2011 • April 1, 2011
Motor, sensory, and autonomic functions can spontaneously return after spinal cord injury. The mechanisms are summarized under the term plasticity. Plasticity includes alterations in spared neuronal c...
KEY FINDING: Plasticity occurs throughout the neuraxis after spinal cord injury, involving alterations in neuronal circuits, axon sprouting, and synaptic rearrangements.
Neurosci Lett, 2009 • June 12, 2009
Spinal cord injury (SCI) results in direct mechanical trauma followed by secondary responses, leading to paralysis and loss of sensation. Current treatment options are inadequate, necessitating therap...
KEY FINDING: SCs can fill cystic cavities, increase white matter sparing, myelinate axons, and promote axonal regeneration in various SCI models.
Neurosci Lett, 2009 • June 12, 2009
Transplantation of OECs or SCs into demyelinated or traumatic spinal cord injuries can improve functional outcome. The formation of cellular tunnels by OECs in the transected spinal cord through which...
KEY FINDING: OECs build unique cellular tunnels through which axons regenerate across a spinal cord transection lesion site.
The Journal of Neuroscience, 2009 • May 13, 2009
The study demonstrates that blocking Nogo receptor ligands with sNgR promotes the regeneration of myelinated sensory axons after dorsal root crush in adult rats. sNgR treatment leads to the regrowth o...
KEY FINDING: Intraventricular infusion of sNgR for 1 month results in extensive regrowth of myelinated sensory axons into the white and gray matter of the dorsal spinal cord.
PNAS, 2009 • June 9, 2009
The study uses 2-photon microscopy to monitor vascular and axonal network changes in living mice after spinal cord lesion, observing regrowth of injured axons and transient upregulation of blood vesse...
KEY FINDING: Injured axons show early explorative sprouting, resulting in extensive regrowth until and past the lesion site within 2 months.
J. Comp. Neurol., 2009 • August 20, 2009
This study investigates serotonergic innervation in the caudal spinal stump of rats after complete spinal transection, focusing on the impact of olfactory ensheathing glia (OEG) transplantation. The r...
KEY FINDING: Many 5-HT-labeled axons are present throughout the caudal stump of both media- and OEG-injected rats after complete spinal cord transection, suggesting the presence of 5-HT-labeled fibers is not a reliable indicator of regeneration.
J Neurochem, 2009 • July 1, 2009
The study demonstrates that inhibiting NF-κB in astrocytes promotes axonal sparing and sprouting after spinal cord contusion injury, contributing to improved functional recovery. Retrograde tracing sh...
KEY FINDING: Inhibition of NF-κB in astrocytes leads to reduced inflammation and improved functional recovery after spinal cord injury.
J Physiol, 2009 • June 15, 2009
The review explores central nervous system regeneration in leeches and neonatal opossums to understand the mechanisms that promote and prevent regeneration, contrasting these with the limited regenera...
KEY FINDING: Leech CNS regeneration involves microglial cells and nitric oxide, which facilitate axon regrowth and reconnection with appropriate synaptic targets.