Latest Research Summaries
Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,491-11,500 of 12,052 results
Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury
Brain, 2010 • August 4, 2010
This study evaluated the analgesic effect of transcranial direct current stimulation (tDCS) of the motor cortex and visual illusion techniques, applied alone or combined, in patients with neuropathic ...
KEY FINDING: The combination of transcranial direct current stimulation and visual illusion significantly reduced the intensity of neuropathic pain more than any of the single interventions.
Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors
J Comp Neurol, 2010 • August 1, 2010
This study investigated the impact of peripheral nerve injury on the central projections of DRG neurons expressing GFRs, focusing on GFRα1, GFRα2, and GFRα3 after sciatic nerve injury in rats. The key...
KEY FINDING: Sciatic nerve injury caused a widespread increase in nerve fiber labeling for GFRα1 in the lumbar dorsal horn.
Improvement of gait patterns in step-trained, complete spinal cord-transected rats treated with a peripheral nerve graft and acidic fibroblast growth factor
Exp Neurol, 2010 • August 1, 2010
The study investigated the effects of peripheral nerve grafts (PNG) and acidic fibroblast growth factor (αFGF) combined with step training on locomotor performance in rats with complete spinal cord tr...
KEY FINDING: PNG plus αFGF treatment resulted in a clear improvement in locomotor performance with or without step training.
Neuronal intrinsic barriers for axon regeneration in the adult CNS
Curr Opin Neurobiol, 2010 • August 1, 2010
The review addresses the challenge of why injured axons in the adult mammalian CNS fail to regenerate after injury. It discusses the limitations of solely targeting extracellular inhibitory molecules ...
KEY FINDING: Removing extracellular inhibitory activities is insufficient for successful axon regeneration in the adult CNS.
Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord
PLoS ONE, 2010 • July 29, 2010
This study investigates the potential of human motor neuron progenitors (hMNPs), derived from human embryonic stem cells (hESCs), to treat spinal cord injury (SCI) in rats. The research demonstrates t...
KEY FINDING: hMNP transplantation suppresses SCI pathogenesis-related signaling pathways, which correlates with enhanced endogenous neuronal survival and neurite branching.
Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
STEM CELLS, 2010 • July 27, 2010
This study evaluated the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult ...
KEY FINDING: Transplanted OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons within the injured spinal cord.
Microarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitro
BMC Neuroscience, 2010 • July 22, 2010
This study investigated the effects of cyclic tensile stresses on cultured rat spinal cord cells using microarray analysis to identify changes in gene expression related to cell death. The results sho...
KEY FINDING: Cyclic tensile stress reduces the viability of cultured spinal cord cells in a dose- and time-dependent manner.
Local and Remote Growth Factor Effects after Primate Spinal Cord Injury
The Journal of Neuroscience, 2010 • July 21, 2010
The study examined the local and remote neuronal responses to neurotrophic factor-secreting cell grafts placed within sites of right C7 hemisection lesions in the rhesus macaque. Six months after gene...
KEY FINDING: Neurotrophic factors (BDNF and NT-3) administered at the site of spinal cord injury in primates promoted regeneration of axons into the local lesion site.
Erratum to: Therapeutic DNA Vaccination as a Repair Strategy Following Spinal Cord Injury
Cell Mol Neurobiol, 2010 • July 14, 2010
This is a retraction note for an article originally published online on July 14, 2010, in Cellular and Molecular Neurobiology. The reason for the retraction is the duplication of a significant amount ...
KEY FINDING: The original article (DOI 10.1007/s10571-009-9449-4) has been retracted.
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
PNAS, 2010 • July 13, 2010
This study investigates the therapeutic potential of induced pluripotent stem (iPS) cells for spinal cord injury (SCI) treatment in mice, emphasizing the importance of pre-evaluating iPS cell safety. ...
KEY FINDING: Pre-evaluated safe iPS cells can differentiate into functional neurons, astrocytes, and oligodendrocytes in vitro.