Latest Research Summaries
Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 51-60 of 12,052 results
Simulation of adult limb regeneration with lizard tail spinal cord implants reveals distinct roles of radial glia and microglia populations
Not specified, 2025 • March 5, 2025
This study demonstrates blastema stimulation in amputated limbs of adult amniotes with application of lizard spinal cord cells Removal of either population inhibits fibroblast proliferation and blaste...
KEY FINDING: Radial glia contribute Hedgehog signals that cause fibroblast proliferation but do not affect fibrosis.
Adeno-associated viruses for efficient gene expression in the axolotl nervous system
PNAS, 2025 • March 5, 2025
This study investigated the functionality and efficiency of AAVs to transduce cells in the axolotl brain, spinal cord, and retina, finding that AAV8, AAV9, and AAVPHP.eB are the most efficient viral v...
KEY FINDING: AAV8, AAV9, and AAVPHP.eB are efficient viral vectors for gene transfer in the axolotl brain and spinal cord.
Centripetal migration and prolonged retention of microglia promotes spinal cord injury repair
Journal of Neuroinflammation, 2025 • March 5, 2025
This study uncovers the criticality of microglial location and abundance in orchestrating SCI repair, highlighting centripetal microglial dynamics as valuable targets for therapeutic intervention. The...
KEY FINDING: Decreased expression and perilesional distribution of CX3CL1 is the primary reason for the limited centripetal migration of microglia.
Deep Brain Stimulation and Brain–Spine Interface for Functional Restoration in Spinal Cord Injury
Biomedicines, 2025 • March 5, 2025
This review explores the integration of neuromodulation technologies like brain-spine interface (BSI), epidural electrical stimulation (EES), and deep brain stimulation (DBS) to restore function in SC...
KEY FINDING: DBS has been effective in treating SCI, with the nucleus raphe magnus (NRM) and periaqueductal gray (PAG) identified as stimulation sites.
Comments on “H4K12 Lactylation-Activated Spp1 in Reprogrammed Microglia Improves Functional Recovery After Spinal Cord Injury”
CNS Neuroscience & Therapeutics, 2025 • March 5, 2025
This letter to the editor provides comments on a research article concerning the role of H4K12 lactylation in promoting Spp1 transcription and aiding functional recovery post-spinal cord injury (SCI)....
KEY FINDING: The original study demonstrated the significant role of recombinant Spp1 protein (rSPP1) in functional recovery after spinal cord injury.
Safety and feasibility of a smart assistive bone-cement injection system: a cadaveric study
Journal of Orthopaedic Surgery and Research, 2025 • March 4, 2025
This study introduces a smart assistive bone-cement injection system for percutaneous vertebral augmentation (PVA) to overcome the shortcomings of currently used injection devices. The smart system de...
KEY FINDING: The motorized injection group had significantly fewer intraoperative X-ray fluoroscopies compared to the manual injection group, indicating reduced radiation exposure for the surgeon.
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects
Materials Today Bio, 2025 • March 4, 2025
The study investigates a combined approach using neural stem cell (NSC) microfibers and umbilical cord mesenchymal stem cell-derived exosomes (ucMSC-exos) to treat complete spinal cord injuries (SCI)....
KEY FINDING: ucMSC-exos can shift microglial polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype.
Associated Factors of Cervical Spinal Cord Injury Without Radiographic Evidence of Trauma: A Retrospective Study
Cureus, 2025 • March 4, 2025
This retrospective study investigated factors associated with SCIWORET in cervical SCI patients, focusing on CCS, cervical OPLL, and DISH. The study found that CCS and cervical OPLL were independent p...
KEY FINDING: CCS was present in 85.7% of the SCIWORET group compared to 53.8% in the SCI with fracture group (p < 0.0001).
Undergrowth Collagen Fibers Analysis by Fingerprint Enhancement Method
Biology of the Cell, 2025 • March 4, 2025
This study introduces a novel method, the fingerprint enhancement (FP-E) algorithm, for analyzing undergrowth collagen fibers, particularly in the context of spinal cord injury (SCI). The FP-E method ...
KEY FINDING: The fingerprint enhancement (FP-E) algorithm effectively detects and characterizes undergrowth collagen fibers in spinal cord injury samples.
Global trends and hotspots of neuromodulation in spinal cord injury: a study based on bibliometric analysis
Journal of Orthopaedic Surgery and Research, 2025 • March 3, 2025
This study analyzed the global trends and hotspots in research on neuromodulation for spinal cord injury (SCI) using bibliometric analysis of publications from 2005 to 2024. The results showed a stead...
KEY FINDING: The number of publications on neuromodulation in SCI showed an increasing trend from 2005 to 2024.