Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 111-120 of 142 results
Brain, 2016 • January 29, 2016
Aging in the central nervous system (CNS) leads to a loss of gray and white matter, contributing to cognitive decline, which is further exacerbated by neurological disorders. This is accompanied by an...
KEY FINDING: Macrophages and microglia, two types of immune cells in the brain, age in distinct ways, with macrophages showing diminished pro-inflammatory responses and microglia exhibiting an exaggerated pro-inflammatory response with age.
Neurosci Lett, 2017 • June 23, 2017
Age is an important consideration for recovery and repair after spinal cord injury, with SCI increasingly affecting older populations. Despite progress in promoting axonal regeneration and repair, und...
KEY FINDING: Axon regeneration declines with age in various systems, including zebrafish and C. elegans, suggesting the involvement of neuron-intrinsic mechanisms.
The Journal of Neuroscience, 2018 • August 29, 2018
The study identifies PRMT8 as a key regulator of stress tolerance in spinal cord motoneurons. PRMT8 maintains ADMA levels, protecting against age-related DNA damage and promoting cell survival. Loss o...
KEY FINDING: Spinal cord motoneurons exhibit high levels of asymmetric dimethyl arginines (ADMAs), providing protection against environmental stress.
Front. Aging Neurosci., 2018 • September 20, 2018
The study investigated the impact of age on microglial responses to demyelination using the cuprizone model in young and middle-aged mice, focusing on the hippocampus and corpus callosum. Results show...
KEY FINDING: Age-related microglial changes in healthy controls were more pronounced in the gray matter region, with higher levels of F4/80 and Marco and lower expression of CD68 in middle-aged mice.
International Journal of Molecular Sciences, 2019 • November 3, 2019
The review focuses on the role of the blood-brain barrier (BBB) and its tight junctions (TJs) in age-related brain disorders. It discusses how age, age-related pathologies, and immune system aging aff...
KEY FINDING: Aging negatively impacts BBB function, increasing paracellular permeability in the aged human brain.
Autophagy, 2020 • November 2, 2020
The study demonstrates that autophagy is essential for axon regeneration, with loss-of-function mutants of autophagy genes displaying impaired axon regeneration. Axon injury induces autophagy in a DLK...
KEY FINDING: Axon injury induces autophagy in neurons, characterized by an increase in autophagosomes and autolysosomes.
Frontiers in Cell and Developmental Biology, 2020 • March 25, 2020
This review examines the evidence for an age-dependent decline in axon growth after CNS injury, focusing on neuron-extrinsic factors. The review highlights how inflammation, astrogliosis, extracellula...
KEY FINDING: Aging exacerbates the inflammatory response after SCI, leading to increased tissue damage and reduced functional recovery.
Front. Aging Neurosci., 2020 • September 23, 2020
This review explores the role of the adaptive immune system in neurodegenerative diseases, highlighting its involvement in both degeneration and regeneration processes. Aging is identified as a key fa...
KEY FINDING: Adaptive immune cells, particularly T lymphocytes, can have both detrimental and beneficial roles in neurodegenerative diseases, influencing both degeneration and regeneration.
Oxidative Medicine and Cellular Longevity, 2021 • February 10, 2021
The study found that RXRα inhibits neurite regeneration and functional recovery after spinal cord injury in rats. It demonstrated that RXRα promotes p66shc expression, which impedes neurite regenerati...
KEY FINDING: RXRα agonists inhibit nerve regeneration after spinal cord injury, while RXRα antagonists promote the regeneration of injured neurites and the recovery of motor function in rats.
R I Med J, 2013 • January 1, 2013
Nerve regeneration is a coordinated process involving cellular dedifferentiation and chemotaxis to create a healing microenvironment. Aging negatively affects this process. Aging-related factors such ...
KEY FINDING: Inflammaging, a state of chronic, low-grade inflammation, impairs peripheral nerve maintenance and regeneration in older individuals.