Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 121-130 of 142 results
PLoS ONE, 2012 • December 7, 2012
This study used genome-scale transcriptional profiling to identify distinct age-dependent expression profiles in rat sensorimotor cortex during acute, subacute and chronic phases of spinal cord injury...
KEY FINDING: Aging significantly alters the cortical transcriptomes triggered by SCI, with little overlap in lesion-regulated genes between young and old animals.
Orthopaedic Surgery, 2025 • January 12, 2025
This study aimed to explore the role of aging and circadian rhythm-related genes in knee osteoarthritis (KOA). Differentially expressed genes (DEGs) were identified from the GEO database and intersect...
KEY FINDING: Identified 75 differentially expressed aging-circadian rhythm related genes between normal and KOA groups, primarily enriched in the circadian rhythm pathway.
Communications Biology, 2025 • January 7, 2025
This study provides a spatiotemporal atlas of young and aged spinal cord tissues using spatial transcriptomics, revealing changes in gene expression between grey and white matter regions. Integration ...
KEY FINDING: Bulk RNA sequencing identified 526 upregulated genes and 300 downregulated genes in senescent spinal cords compared to young spinal cords, with pathways related to phagosome function, neuroinflammation, ferroptosis, and necroptosis being enriched.
Aging Cell, 2009 • April 1, 2009
This study characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. The data r...
KEY FINDING: Internode lengths of rubrospinal tract axons significantly decrease with age, suggesting active remyelination.
International Journal of Biological Sciences, 2024 • January 1, 2024
This study demonstrates the depletion of the selective autophagy receptor NBR1 in NPCs during the degeneration process, leading to the buildup of SRBD1 within NPCs, thereby accelerating NPCs senescenc...
KEY FINDING: NBR1 expression is downregulated in degenerative nucleus pulposus cells (NPCs) in human and rat models of intervertebral disc degeneration (IDD).
Advanced Science, 2024 • June 19, 2024
This study reveals that CKB promotes mitochondrial ATP production by inhibiting AKT activation, which in turn reduces mitochondrial calcium levels and mPTP activity. The CKB-AKT signaling axis plays a...
KEY FINDING: CKB is essential for maintaining cellular sensitivity to F1F0 ATP synthase inhibition, a key enzyme in mitochondrial ATP production.
European Journal of Trauma and Emergency Surgery, 2025 • January 25, 2025
This study evaluated the predictive ability of various frailty scores for adverse outcomes in surgically managed isolated traumatic spinal injury (TSI) patients without spinal cord injury. Simpler fra...
KEY FINDING: The 5-mFI and 11-mFI outperformed other scores in predicting in-hospital mortality, any complication, and failure-to-rescue (FTR).
Nature Communications, 2024 • June 14, 2024
This study identifies dos-3 as a key gene mediating the cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of germline stem/progenitor cells (GSPCs) in C. elegans. DOS-3, a non-...
KEY FINDING: dos-3 encodes a non-canonical Notch ligand and is upregulated by DAF-16/FOXO activity in aging PSG cells of animals with reduced IIS.
Scientific Reports, 2016 • September 2, 2016
This study investigates the age-related changes in healthy mouse Achilles tendon tissue and identifies a previously unknown role of Sparc in tendons. The findings demonstrate that Sparc expression dec...
KEY FINDING: Sparc expression significantly decreases in healthy-aged mouse Achilles tendons.
Exp Neurol, 2008 • March 1, 2008
The study examined locomotor recovery and myelin pathology in young and aged rats following contusion SCI, finding that aged rats had delayed recovery and greater pathology. Voluntary exercise, both p...
KEY FINDING: Aged rats exhibit a delayed rate of locomotor recovery following SCI compared to young rats and demonstrate a greater degree of pathology and demyelination.