Browse the latest research summaries in the field of biochemistry for spinal cord injury patients and caregivers.
Showing 31-37 of 37 results
PNAS, 2017 • December 26, 2017
Glycosaminoglycans (GAGs) are important in biological processes, but structural information on their protein complexes is limited. The study introduces GAG-Dock, a computational method to predict GAG-...
KEY FINDING: The GAG-Dock method accurately reproduces the binding poses of heparin to proteins, as validated against known crystal structures.
Exp Neurol, 2011 • October 1, 2011
This study demonstrates that acute MMP-9/2 inhibition after spinal cord dorsal hemisection acts as a mitogen for NG2+ cells but not GFAP+ astrocytes or Iba-1+ macrophages and/or microglia. In the dama...
KEY FINDING: Acute inhibition of MMP-9/2 after spinal cord injury increases the proliferation of NG2+ progenitor cells but not astrocytes or microglia.
Nature Communications, 2023 • October 27, 2023
This study introduces a 'psoriasis catalytic therapy' strategy using biomimetic materials (FeN4O2-SACs) to continuously scavenge overexpressed ROS, thereby ameliorating psoriatic lesions and preventin...
KEY FINDING: FeN4O2-SACs exhibit multiple enzyme-mimicking activities, analogous to natural antioxidant enzymes, demonstrating broad-spectrum ROS scavenging capability.
Advanced Science, 2022 • August 25, 2022
This review explores biomimetic strategies for constructing photoelectrocatalytic (PEC) interfaces to mimic natural photosynthesis for CO2 conversion. It discusses various biomimetic PEC interfaces, i...
KEY FINDING: Biomimetic PEC interfaces can be constructed using metal cocatalysts/semiconductors, small molecules/semiconductors, molecular catalysts/semiconductors, MOFs/semiconductors, and microorganisms/semiconductors.
Neural Regeneration Research, 2021 • February 19, 2021
This review focuses on the role of post-translational modifications (PTMs) in influencing axonal growth, functional recovery, and neuropathic pain following spinal cord injury (SCI). The authors highl...
KEY FINDING: PTMs like phosphorylation, acetylation, detyrosination, and polyglutamylation modify tubulin, influencing microtubule functions essential for neurite outgrowth and growth cone guidance during nerve regeneration after SCI.
Explor Neuroprotective Ther., 2024 • January 1, 2024
This review describes the roles of S1P and LPA receptors in neurodegeneration and potential neuroprotection. Fingolimod, an S1P receptor agonist, is clinically used for multiple sclerosis and shows ne...
KEY FINDING: Fingolimod, an S1P receptor agonist, is clinically effective in multiple sclerosis and shows neuroprotective effects in various neuropathologies, including stroke and Alzheimer’s disease.
J Neuropathol Exp Neurol, 2013 • November 1, 2013
This study investigates the involvement of kallikreins (KLKs) in traumatic spinal cord injury (SCI) by examining their expression patterns in human and murine SCI models, as well as their effects on n...
KEY FINDING: Temporally and spatially distinct changes in kallikrein expression were observed with partially overlapping patterns between human and murine SCI, including peak elevations (or reductions) during the acute and subacute periods.