Browse the latest research summaries in the field of biophysics for spinal cord injury patients and caregivers.
Showing 1-10 of 10 results
Biophysical Journal, 2018 • September 4, 2018
This study uses Brillouin microscopy to map the mechanical properties of spinal cord tissue in living zebrafish larvae during development and after spinal cord injury, providing a non-destructive metho...
KEY FINDING: The Brillouin shift within the spinal cord remained comparable during development, indicating stable mechanical properties.
MOLECULAR MEDICINE REPORTS, 2019 • January 1, 2019
The study investigates the effect of low-frequency pulsed electromagnetic fields (LPEMFs) on spinal cord injury (SCI) in rats, focusing on inflammation, oxidative stress, and HSP70 levels. Results sho...
KEY FINDING: LPEMFs significantly promoted functional recovery following spinal cord injury, as demonstrated by an increased Basso, Beattie and Bresnahan score.
European Journal of Neuroscience, 2025 • February 1, 2025
The study investigates the effects of extremely low-frequency and low-intensity electromagnetic fields (ELF-EMF) on microtubules (MTs) and Tau-MT interactions in a neuronal cell model exposed to zinc ...
KEY FINDING: Timed pre-exposure to ELF-EMF (40 Hz, 1 G) enhanced microtubule dynamics, specifically increasing EB1 comet tracks' length with a 10 min (48 h) treatment.
Biophysical Reviews, 2024 • October 5, 2023
New optical techniques in neuroscience advance understanding of neurological conditions. They show potential in unraveling processes and evaluating therapies for spinal cord injury, peripheral nerve i...
KEY FINDING: Coherent Raman scattering and third harmonic generation enable label-free visualization of myelin sheaths. Combining these with two-photon excited autofluorescence and second harmonic generation allows comprehensive tissue visualization.
Analytical and Bioanalytical Chemistry, 2018 • April 18, 2018
Neural progenitor cells were cultured on electrospun P(HB-co-HHx) fiber substrates coated with either laminin or poly-L-lysine/laminin. At different times after cell seeding, the samples were fixed an...
KEY FINDING: Changes in lipid and amide I–II spectral regions are modulated by the type and coating of the substrate used and the culture time.
Langmuir, 2024 • December 9, 2024
This study introduces a computational framework to investigate the interactions between SAP fibrils and neuronal membranes using coarse-grained molecular dynamics simulations. The simulations reveal t...
KEY FINDING: LDLK3 monomers and AQP4 cause different structural perturbations in the neural membrane that may be interpreted as different lipid fingerprints.
PNAS, 2017 • December 26, 2017
Glycosaminoglycans (GAGs) are important in biological processes, but structural information on their protein complexes is limited. The study introduces GAG-Dock, a computational method to predict GAG-...
KEY FINDING: The GAG-Dock method accurately reproduces the binding poses of heparin to proteins, as validated against known crystal structures.
Nanoscale Advances, 2019 • January 1, 2019
This study introduces a method for the rapid synthesis of red-emitting copper nanoclusters (R-CuNCs) using green-emitting copper nanoclusters (G-CuNCs) as assistants, while preserving their water solu...
KEY FINDING: G-CuNCs can assist in the fast formation of R-CuNCs, retaining their tiny size and water solubility.
J Cell Physiol, 2015 • July 1, 2015
This study investigates the migration of Schwann cells in electric fields (EFs), finding that they migrate towards the anode, with increased directedness and displacement at higher EF strengths. RNA s...
KEY FINDING: Schwann cells migrate towards the anode in an applied electric field, and the directedness and displacement of migration increase with the strength of the electric field.
ACS Omega, 2018 • November 2, 2018
The study demonstrates a method for fabricating aggregated L-cysteine-protected copper nanoclusters into 3D nanomaterials with a mesoporous sphere structure using Ce3+ as a crosslinking agent. The int...
KEY FINDING: Ce3+ ions can be used to crosslink and rearrange L-cysteine-protected copper nanoclusters into ordered mesoporous spheres.