Browse the latest research summaries in the field of biochemistry for spinal cord injury patients and caregivers.
Showing 11-20 of 37 results
J Comp Neurol, 2012 • October 15, 2012
This report describes an increase in sulfated CS-GAG expression in the injury core and in a tight band surrounding it, and a decrease in the number of PNNs and the level of aggrecan and phosphacan in ...
KEY FINDING: TBI resulted in an increase in the CSPGs neurocan and NG2 expression in a tight band surrounding the injury core, which overlapped with the presence of 4-sulfated CS GAGs but not with 6-sulfated GAGs.
Neural Regen Res, 2023 • July 1, 2023
This review summarizes the important metabolic pathways involved in SCI as well as the importance of enolase activity on the cell surface following SCI. Interaction at the cell surface allows enolase ...
KEY FINDING: Enolase promotes both pro- and anti-inflammatory events and regulates functional recovery in SCI.
J. Proteome Res., 2022 • May 4, 2022
This study aimed to improve understanding of spinal cord injury pathology by examining glycosylation changes following injury in both rat and Xenopus models. The researchers investigated how an aligne...
KEY FINDING: Following SCI in rats, complex and outer-arm fucosylated glycans decreased, while oligomannose and hybrid structures increased.
Int J Clin Exp Pathol, 2017 • November 15, 2017
This study investigates the impact of gene silencing non-muscle myosin II (NMII) on axonal regeneration following spinal cord injury (SCI) in rats. The research demonstrates that phosphorylated NMII l...
KEY FINDING: Phosphorylated NMII level was up-regulated after SCI, suggesting it may inhibit neuronal survival and axonal regeneration.
Neural Regeneration Research, 2023 • September 1, 2023
The review focuses on the role of matrix metalloproteases (MMPs) in spinal cord injury (SCI) and the potential of MMP inhibitors as a therapeutic strategy. MMPs contribute to several detrimental proce...
KEY FINDING: MMP-9 and MMP-2 are upregulated after SCI, contributing to BSCB breakdown, inflammation, and apoptosis.
The Journal of Neuroscience, 2019 • March 13, 2019
This study establishes a workflow template from cell culture to animals in which microtubule-based treatments can be tested for their effectiveness in augmenting regeneration of injured axons relevant...
KEY FINDING: Knockdown of fidgetin resulted in faster-growing axons on both laminin and aggrecan and enhanced crossing of axons from laminin onto aggrecan in vitro.
European Journal of Neuroscience, 2025 • February 1, 2025
The study investigates the effects of extremely low-frequency and low-intensity electromagnetic fields (ELF-EMF) on microtubules (MTs) and Tau-MT interactions in a neuronal cell model exposed to zinc ...
KEY FINDING: Timed pre-exposure to ELF-EMF (40 Hz, 1 G) enhanced microtubule dynamics, specifically increasing EB1 comet tracks' length with a 10 min (48 h) treatment.
Asian Spine Journal, 2015 • February 1, 2015
This study examined the expression of Hyal-4 in a rat spinal cord hemisection model to understand its role in CSPG degradation after injury. The results showed that CSPGs peaked at 3 weeks post-injury...
KEY FINDING: CSPGs appeared at the injury site at 4 days after hemisection, reached a peak after 3 weeks, and then decreased.
Glia, 2008 • January 15, 2008
This study investigates the role of NG2, a chondroitin sulfate proteoglycan, in tPA-mediated plasmin generation and its implications for spinal cord injury recovery. The findings indicate that NG2 act...
KEY FINDING: NG2 binds to both tPA and plasminogen, accelerating the conversion of plasminogen to plasmin.
The EMBO Journal, 2003 • May 13, 2003
This study investigates the binding properties of the Nogo-66 receptor (NgR) and its related proteins, NgR2 and NgR3, to myelin-derived inhibitors of axon regeneration, Nogo, MAG, and OMgp. Deletion a...
KEY FINDING: The entire LRR region of NgR is necessary for the binding of Nogo, MAG, and NgR itself to cell-surface NgR.