Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 201-210 of 334 results
Curr Protoc Essent Lab Tech, 2013 • January 1, 2013
Quantification of immunohistochemistry (IHC) and immunofluorescence (IF) using image intensity depends on a number of variables. These variables add a subjective complexity in keeping a standard withi...
KEY FINDING: FFT allows for an objective quantification of photomicrographs based on morphology, which reduces the subjectivity associated with pixel-intensity methods.
PNAS, 2021 • April 7, 2021
This study presents the chromosome-level assembly of the giant axolotl genome, providing a valuable resource for understanding genome organization, evolution, and gene regulation in this important mod...
KEY FINDING: The chromosome-scale assembly of the 32 Gb axolotl genome was achieved using Hi-C contact data.
Journal of Neurotrauma, 2021 • August 1, 2021
The study tracked serological markers over one year following spinal cord injury, finding that most markers normalized within 6-12 months, with injury severity affecting these levels. Differences betw...
KEY FINDING: Most serological markers were at pathological levels at baseline but returned to normal values within 6–12 months post-injury.
eLife, 2021 • May 14, 2021
This study investigates the mechanisms underlying spinal cord regeneration in axolotls, focusing on the spatiotemporal pattern of cell proliferation. It demonstrates that the regenerative response is ...
KEY FINDING: Spinal cord regeneration is consistent with a signal that recruits ependymal cells during approximately 85 hours after amputation within approximately 830 μm of the injury.
J. Exp. Med, 2021 • August 2, 2021
This study used single-cell RNA sequencing to generate a detailed transcriptomic profile of cells at the spinal cord injury site. The researchers identified major cell types and their interactions dur...
KEY FINDING: The study identified distinct temporal regulation of angiogenesis, gliosis, and fibrosis by myeloid subtypes.
Frontiers in Neuroscience, 2021 • May 28, 2021
This study investigated the potential of serum SELENBP1 as a biomarker for traumatic spinal cord injury (TSCI). The researchers analyzed serum samples from patients with TSCI, comparing SELENBP1 level...
KEY FINDING: Serum SELENBP1 concentrations are elevated in patients with more severe neurological impairment (AIS A) compared to those with less severe impairment (AIS B-D) at the time of admission.
Crit Care, 2021 • June 29, 2021
This study identifies CEA as a potential biomarker for COVID-19 patients, exploring its underlying mechanism through single-cell transcriptomics. The research reveals that developing neutrophils/neutr...
KEY FINDING: CEA was identified as the only laboratory indicator with a significant difference in both univariate and multivariate analyses.
Journal of Pathology Informatics, 2022 • December 20, 2022
This study investigates the use of generative adversarial networks (GANs) to enhance the quality of frozen section images by translating them into virtual paraffin sections, aiming to improve diagnost...
KEY FINDING: Pathologists' detection accuracy of virtual paraffin sections was between 0.62 and 0.97, indicating a challenge in distinguishing real from AI-generated images.
BIOENGINEERED, 2021 • August 23, 2021
This study identifies alternative splicing events associated with bladder cancer bone metastasis and constructs a predictive model for prognosis. The research proposes a regulatory mechanism involving...
KEY FINDING: Alternative splicing events (ASEs) are associated with the occurrence and progression of bladder cancer and have a relationship with its prognosis.
Photoacoustics, 2021 • August 26, 2021
This study investigates the feasibility of using multi-wavelength photoacoustic (MWPA) analysis to detect collagen in bone as a biomarker for bone health assessment, focusing on the wavelength range o...
KEY FINDING: The study successfully demonstrated the feasibility of using multi-wavelength photoacoustic (MWPA) analysis for detecting collagen content in bone.