Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 191-200 of 334 results
Lifetime Data Anal, 2018 • July 1, 2018
This paper introduces a semi-parametric method for estimating conditional state occupation probabilities in multistate models with right-censored data, using inverse censoring probability re-weighting...
KEY FINDING: The proposed method demonstrates reasonable performance, with a clear decline in the error rate as the sample size increases for all types of censoring and rates.
Cell Transplantation, 2017 • July 1, 2017
This study investigates gene expression patterns in the brain after spinal cord injury (SCI) in mice, focusing on acute (3 hours) and subacute (2 weeks) phases post-injury. Transcriptome analysis reve...
KEY FINDING: At the acute phase after SCI, the oxidative phosphorylation pathway in the brain is affected, indicating impaired energy production.
JOURNAL OF NEUROTRAUMA, 2018 • August 1, 2018
This study investigated gene expression in individuals with chronic SCI compared to uninjured individuals to understand immune dysfunction. The study identified differentially expressed genes related ...
KEY FINDING: There is a marked downregulation of natural killer cell genes in individuals with chronic SCI.
Neural Regeneration Research, 2018 • September 1, 2018
This mini-review discusses two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI to identify therapeutic strategies t...
KEY FINDING: Individuals with SCI levels rostral to T5, where sympathetic nervous system disruption would occur, had more differentially expressed genes (N = 2226) compared to able-bodied participants.
Frontiers in Neurorobotics, 2018 • August 10, 2018
This study designed an artificial neural network (ANN) to predict torque exerted around the knee joint by the quadriceps muscle using mechanomyography (MMG) parameters during FES isometric knee extens...
KEY FINDING: ANN models using MMG data (RMS and RMS-ZC) can predict knee extension torque during FES with reasonable accuracy.
eLife, 2018 • October 2, 2018
This study uses an integrated systems biology approach to understand the molecular mechanisms underlying spinal cord injury (SCI) pathophysiology. Large-scale RNA-seq data from healthy subjects was le...
KEY FINDING: Systematic literature analysis identified 695 unique human genes associated with the response to SCI by small-scale experiments.
Neural Regen Res, 2019 • May 1, 2019
This study investigated the relationship between tau protein levels in serum and cerebrospinal fluid (CSF) and the severity and functional outcome of traumatic spinal cord injury (SCI) in rats. The st...
KEY FINDING: Tau protein levels in serum and CSF increased rapidly after SCI, peaking at 12 hours.
Front. Mol. Neurosci., 2019 • January 14, 2019
The study investigated circRNA expression patterns in rats after traumatic SCI using microarray and qRT-PCR, identifying 1676 differentially expressed circRNAs. Bioinformatics analysis predicted circR...
KEY FINDING: A total of 1676 differentially expressed circRNAs were found in spinal cord 3 days after contusion. 1261 circRNAs were significantly downregulated, whereas the remaining 415 were significantly upregulated.
MOLECULAR MEDICINE REPORTS, 2019 • January 1, 2019
The study aimed to identify critical genes and mechanisms involved in spinal cord injury (SCI) using gene expression profiles from trkB.T1 knockout mice. Differentially expressed genes (DEGs) were scr...
KEY FINDING: A total of 664 DEGs in the sham group and SCI groups at days 1, 3, and 7 following injury were identified in trkB.T1 KO mice.
PM R, 2014 • April 1, 2014
This study investigated monocyte phenotypes in acute SCI and their correlation with circulating cytokine profiles. The study identified distinct M1/M2 monocyte dominance in SCI patients, correlating w...
KEY FINDING: Patients with SCI exhibit either M1-dominant or M2-dominant circulating monocytes (MOs), which are distinct from uninjured controls.