Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 321-330 of 334 results
Antioxidants, 2020 • May 13, 2020
This study investigated the dynamics of serum zinc concentrations in patients with traumatic spinal cord injury (TSCI) and their correlation with neurological impairment. Serum samples were collected ...
KEY FINDING: The median Zn concentrations in the study group dropped significantly within the first 9 hours after injury, with a more substantial decline compared to control subjects.
Computational Intelligence and Neuroscience, 2020 • May 20, 2020
This study investigated the prediction of cognitive decline in patients with temporal lobe epilepsy (TLE), mild cognitive impairment (MCI), and subjective cognitive complaints using EEG, MRI, and neur...
KEY FINDING: The best sensitivity/specificity for decline was 72%/82% for executive functions based on a feature combination from MRI volumetry and EEG partial coherence during recall of memories.
Curr Opin Genet Dev, 2020 • October 1, 2020
The spiny mouse (Acomys) exhibits exceptional regenerative abilities in various tissues and organs compared to typical mammals. Regeneration in Acomys is associated with a blunted inflammatory respons...
KEY FINDING: Acomys can regenerate skin, including hair follicles, sebaceous glands, dermis, and muscle, without forming scars after excisional wounds or burns.
International Journal of Medical Sciences, 2020 • July 6, 2020
The study identifies shared biological pathways between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM) by analyzing gene expression data. Lipid metabolism is highlighted as a key interse...
KEY FINDING: 113 communal differentially expressed genes (DEGs) were identified between PD and T2DM.
BMC Genomics, 2020 • July 13, 2020
This study aimed to identify the genetic architecture of the cerebrum in chickens and compare gene expression regulation across different brain regions and somatic tissue. The study identified one can...
KEY FINDING: One candidate gene, MTF2, was identified as potentially regulating cerebrum size, and it has previous links to brain development.
BMC Genomics, 2020 • August 6, 2020
This study identifies deep, phylogenetically conserved commonalities between CNS axon regeneration and other examples of successful tissue regeneration and provides new targets for studying the molecu...
KEY FINDING: A set of 324 genes ("DESR genes") were differentially expressed in regenerative CNS regions (optic nerve and tadpole spinal cord) but not in non-regenerative regions.
BMC Genomics, 2004 • August 13, 2004
The study developed expressed sequence tags (ESTs) for the Mexican axolotl (Ambystoma mexicanum) and the Eastern tiger salamander (A. tigrinum tigrinum) from various tissues, including regenerating li...
KEY FINDING: Approximately 40,000 cDNA sequences were isolated for A. mexicanum and A. t. tigrinum from various tissues.
EBioMedicine, 2021 • February 1, 2021
This study aimed to identify a serum lipid signature associated with subsequent cognitive decline in the Three-City study. The researchers measured 189 serum lipids in a case-control sample nested wit...
KEY FINDING: Lower levels of the triglyceride TAG50:5, and of four membrane lipids (sphingomyelin SM40:2,2, phosphatidylethanolamine PE38:5(18:1/20:4), ether-phosphatidylethanolamine PEO34:3(16:1/18:2), and ether-phosphatidylcholine PCO34:1(16:1/18:0)), and higher levels of PCO32:0(16:0/16:0), were associated with greater odds of cognitive decline.
Frontiers in Cellular Neuroscience, 2021 • January 28, 2021
This study provides a comprehensive proteomic and secretomic characterization of human neural stem cells (NSCs) during in vitro differentiation. NSCs were differentiated spontaneously or with trophic ...
KEY FINDING: Substantial protein differences were identified in the early stages of NSC differentiation. More than a third of all the proteins were regulated, including known neuronal and NSC multipotency markers.
PLOS Genetics, 2021 • March 24, 2021
This study comprehensively characterized the temporal dynamic gene expression profile and epigenetic status during early cortical development, uncovering molecularly heterogeneous subpopulations withi...
KEY FINDING: Identified a new set of coding genes and lncRNAs involved in early neuronal differentiation and validated with functional assays in vitro and in vivo.