Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 311-320 of 334 results
Neural Regen Res, 2019 • July 1, 2019
This study aimed to identify potential genes/pathways and clarify the mechanisms underlying SCI at the molecular level. The results show that many inflammation-related pathways are upregulated in the ...
KEY FINDING: Identified 109 upregulated genes and 30 downregulated genes with consistent expression changes across multiple time points after SCI.
Frontiers in Neuroinformatics, 2019 • April 5, 2019
The project MEEGIPS, a Modular EEG Investigation and Processing System for visual and automated detection of HFOs, introduces a highly user friendly software that includes five of the most prominent au...
KEY FINDING: MEEGIPS is a highly user friendly software that includes five of the most prominent automated detection algorithms.
The Journal of Spinal Cord Medicine, 2021 • March 1, 2021
This study examined the role of hemoglobin (Hb) dynamics as a potential early biomarker for neurological remission in patients with traumatic spinal cord injury (TSCI). The study found that elevated H...
KEY FINDING: Elevated mean Hb concentrations were observed in the group with neurological remission (G1) from the third day to 1 month compared to the group without remission (G0).
Mol. Nutr. Food Res., 2019 • July 9, 2019
This study used untargeted metabolomics to identify a serum signature of 22 metabolites associated with cognitive decline in older adults over 12 years. The signature included metabolites related to c...
KEY FINDING: A baseline serum signature of 22 metabolites was associated with subsequent cognitive decline.
J Evid Based Med, 2019 • September 1, 2019
This systematic review aimed to determine the median sample size in clinical trials involving individuals with spinal cord injury (SCI) and to examine the statistical methods used in small-sample size...
KEY FINDING: The median total sample size across the included studies was 18 individuals.
Frontiers in Bioengineering and Biotechnology, 2019 • October 15, 2019
This study aimed to identify alternative splicing events (ASEs) associated with prognosis and metastasis in kidney renal clear cell carcinoma (KIRC) using bioinformatic analysis of TCGA data. In this ...
KEY FINDING: Identified 6,081 overall survival-related ASEs (OS-SEs) in KIRC. A total of prognostic 6,081 overall survival-related ASEs (OS-SEs) were identified by univariate Cox regression analysis
Neural Regen Res, 2020 • January 9, 2020
This study investigated the changes in mRNA expression in the spinal cord following sciatic nerve injury in mice using RNA sequencing. The results revealed that the number of differentially expressed ...
KEY FINDING: A total of 1915 differentially expressed mRNAs were identified in the spinal cord following sciatic nerve injury.
Frontiers in Bioengineering and Biotechnology, 2020 • February 19, 2020
This study aimed to identify key genes and cellular components involved in SCI-related neuropathic pain using transcriptome bioinformatics analysis. The analysis revealed that HAVCR2, a receptor on NK...
KEY FINDING: Identified 2,314 genes as differentially expressed between SCI patients and healthy controls.
ADVANCES IN WOUND CARE, 2020 • May 1, 2020
This study analyzes differential protein abundance of PU tissue from SCI patients using high-throughput protein identification and quantification by TMT followed by LC-MS/MS. The study identified 76 p...
KEY FINDING: The study identified 76 proteins with differences in abundance between PU and control tissue.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.