Browse the latest research summaries in the field of brain injury for spinal cord injury patients and caregivers.
Showing 121-128 of 128 results
Current Neuropharmacology, 2020 • May 7, 2020
This review highlights the role of transcription factors and protein biomarkers in the progression of SCI and TBI, emphasizing their potential as therapeutic targets. Clinical observations and MRI ima...
KEY FINDING: NF-κB is a key molecule in secondary damage caused by inflammation after an injury and is essential for the inflammatory response of macrophages, microglia, and astrocytes.
BMC Musculoskeletal Disorders, 2020 • August 3, 2020
This study demonstrates that the neutrophil-to-lymphocyte ratio (NLR) at hospital admission is an independent predictor of 6-month outcomes in patients with acute cervical traumatic spinal cord injury...
KEY FINDING: Elevated NLR at admission is an independent predictor of poorer 6-month outcomes in patients with acute cervical tSCI.
Neural Regen Res, 2021 • October 9, 2020
Central nervous system injury can have significant lasting effects, and there are no comprehensive treatments available. Epothilones, a family of microtubule stabilizing agents, show potential for imp...
KEY FINDING: Epothilone B (EpoB) therapy following spinal cord injury led to increased axon outgrowth, reduced scarring, and improved functional recovery in female rats.
JOURNAL OF NEUROTRAUMA, 2009 • March 1, 2009
Mild to moderate hypothermia has shown promise in protecting the brain and spinal cord after injury in animal models. The mechanisms behind hypothermic protection involve various cellular, biochemical...
KEY FINDING: Mild hypothermia can improve functional outcomes in transient global ischemia models, including sensorimotor and cognitive functions.
British Journal of Pharmacology, 2009 • May 5, 2009
Traumatic brain injury (TBI) is a major public health problem lacking effective drug treatments. Progress in spinal cord injury research provides optimism for developing neuroregenerative therapies fo...
KEY FINDING: Axonal retraction bulbs are dynamic structures, not static markers of failed regeneration, suggesting they can be therapeutically targeted.
J Comp Neurol, 2010 • March 1, 2010
The study investigates the long-term effects of lateral frontal motor cortical injury on the corticospinal projection (CSP) from the supplementary motor cortex (M2). It demonstrates that recovery from...
KEY FINDING: Recovery of dexterous movements from isolated lateral frontal injury is accompanied by selective contralateral terminal axon sprouting and bouton proliferation that is restricted to spinal laminae VII and IX.
Brain Res, 2010 • April 6, 2010
This study investigates how diffuse traumatic brain injury (TBI) affects the activation and reorganization of the whisker-barrel circuit in rats. The researchers hypothesized that the extent of functi...
KEY FINDING: Whisker somatosensory regions of the cortex and thalamus maintained cellular composition as visualized by Nissl stain.
Neuroscientist, 2010 • April 1, 2010
MMPs are implicated in both injury and recovery processes following CNS trauma. Early MMP activity is generally detrimental, promoting barrier dysfunction and inflammation, while later MMP activity mo...
KEY FINDING: MMP-9 is elevated early after injury and is associated with blood-brain barrier disruption and inflammation, while MMP-2 is upregulated later and involved in wound healing.