Browse the latest research summaries in the field of brain injury for spinal cord injury patients and caregivers.
Showing 11-20 of 128 results
Brain and Spine, 2024 • April 10, 2024
This study examined neurotrauma cases from falls in Ethiopia, highlighting a high incidence of injuries at construction sites due to inadequate safety measures. The research revealed significant delay...
KEY FINDING: Falls at construction sites were a major cause of both SCI and TBI, with inadequate safety measures contributing to the severity of injuries.
Scientific Reports, 2022 • December 15, 2022
This study compared polytrauma patients with severe traumatic cervical spine injuries (TCSI) to those with severe traumatic brain injuries (TBI), revealing differences in epidemiology, demographics, a...
KEY FINDING: The incidence of severe TCSI in polytrauma patients was lower than that of severe TBI.
Brain Communications, 2023 • February 13, 2023
This study examined the effects of pioglitazone on mitochondrial function and cortical tissue sparing following mild brain contusion in mice. The researchers used a controlled cortical impact (CCI) mo...
KEY FINDING: Early pioglitazone treatment (0.25 h post-injury) restores maximal mitochondrial respiration in total and synaptic fractions of cortical mitochondria after mild controlled cortical impact.
Frontiers in Cellular Neuroscience, 2023 • March 29, 2023
The study investigates the response of dorsal root ganglion neurons (DRGN) to mechanical stretch injury, comparing them to cortical neurons, in an in vitro model of traumatic brain injury (TBI). Resul...
KEY FINDING: DRGN and cortical axons exhibit similar morphological changes, including undulation formation, elongation, and recovery, in response to severe stretch injury.
Cells, 2023 • May 22, 2023
This study investigates the role of LRP1 in mitochondrial function following traumatic brain injury (TBI) and oxidative stress. Using both in vivo (mtD2g mice) and in vitro (WT and LRP1 knockout MEF c...
KEY FINDING: Oxidative stress increased the quantity of fragmented and spherical-shaped mitochondria in the injury core of the ipsilateral cortex following TBI.
Front. Cell. Neurosci., 2023 • August 9, 2023
Ferroptosis plays a significant role in ACNSI, particularly in secondary injury mechanisms, with mitochondrial dysfunction being a key contributor. Malfunctioning mitochondria can trigger oxidative st...
KEY FINDING: ACNSI can induce mitochondrial dysfunction, highlighting the importance of the mitochondrial connection to ferroptosis.
Brain, 2024 • October 21, 2023
This study investigated the role of PACAP-38 in post-traumatic headache (PTH) by conducting a randomized, double-blind, placebo-controlled trial. The results demonstrated that PACAP-38 infusion induce...
KEY FINDING: Intravenous infusion of PACAP-38 induced migraine-like headache in 95% of participants with persistent PTH, compared to 10% after placebo.
Curr. Issues Mol. Biol., 2023 • October 25, 2023
Neuroinflammation significantly impacts stroke and spinal cord injury, affecting their pathophysiology, progression, and resolution by involving oxidative stress, damage, and cell death. Diagnosis inv...
KEY FINDING: Neuroinflammation plays a critical role in the pathophysiology of stroke and spinal cord injury, affecting motor function.
Neurochem Int, 2024 • March 1, 2024
Mild mitochondrial uncoupling is a novel therapeutic approach for TBI and accumulating evidence suggests that it can restore neurobehavioral outcomes. We propose in this article that mitochondrial unc...
KEY FINDING: Deficits in mitochondrial function and metabolism are considered driving forces in progressive energy crisis developed after TBI.
Frontiers in Neurology, 2024 • February 21, 2024
Neuroinflammation in the context of acquired traumatic CNS injury underscores the complexity and multifaceted nature of the neuroimmune response. Recent advances in understanding the metabolic and phe...
KEY FINDING: Neuroinflammation plays a pivotal role in both the acute and chronic phases of CNS injuries, with the potential to either exacerbate damage or contribute to recovery.