Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 141-150 of 158 results
Scientific Reports, 2018 • August 7, 2018
The study successfully delivered IFN-α mRNA to human skin explants using biolistic application. Optimized IFN-α mRNA sequence variants resulted in significantly higher IFN-α protein expression compare...
KEY FINDING: Skin explants remained viable and intact for at least five days, making them suitable for testing.
Spinal Cord Series and Cases, 2020 • May 25, 2020
This retrospective study evaluated the efficacy of coccygectomy for preventing the recurrence of coccygeal pressure ulcers in individuals with paraplegia. The study found that coccygectomy, combined w...
KEY FINDING: Coccygectomy, in addition to rotation flap surgery, is a suitable method for recurrence prevention of pressure ulcer in the coccygeal area.
Regen Med, 2009 • March 1, 2009
The study demonstrates that a Cx43 carboxyl-terminal peptide (ACT1) can accelerate wound closure and improve the quality of skin healing in both mouse and pig models. ACT1 treatment leads to reduced i...
KEY FINDING: Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin.
Advanced Science, 2023 • November 24, 2022
This review summarizes the microenvironmental characteristics of DFU, presents the main progress of wound healing, and summaries the state-of-the-art therapeutic strategies for DFU. The DFU clinical t...
KEY FINDING: The review highlights the complex microenvironment of DFUs, characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and high protease activity, all hindering the normal wound healing process.
Top Spinal Cord Inj Rehabil, 2016 • December 1, 2016
This article outlines a structured plan and collaborative approach between researchers and community members in developing a pressure ulcer model of care while taking into account perceived facilitato...
KEY FINDING: The study identified key barriers to implementing EST, including a lack of collaboration and communication among healthcare providers across different settings.
J Eur Acad Dermatol Venereol, 2025 • January 1, 2025
The study investigated plasma levels of CGRP in individuals with rosacea and healthy controls to understand CGRP's role in rosacea pathogenesis. The results showed elevated plasma levels of CGRP in in...
KEY FINDING: Plasma levels of CGRP were significantly higher in individuals with rosacea compared to healthy controls after adjusting for age and sex.
Eur J Transl Myol, 2018 • February 22, 2018
The study aimed to determine if long-term home-based Functional Electrical Stimulation (h-bFES) affects the skin in SCI patients with denervated muscles. Skin biopsies were analyzed before and after t...
KEY FINDING: The skin biopsies data of three subjects, taken together, present indeed a statistically significant 30% increase in the area of the epidermis after two years of h-bFES.
International Wound Journal, 2016 • January 1, 2016
This systematic review and meta-analysis assessed the effect of electrical stimulation therapy (EST) on pressure ulcer healing in individuals with spinal cord injury (SCI). The meta-analysis, includin...
KEY FINDING: EST significantly decreased pressure ulcer size by 1.32%/day compared to standard wound care or sham EST.
Dev Cell, 2024 • February 26, 2024
The study dissects macrophage phenotypes in spiny mice (Acomys spp.) that regenerate ear pinnae tissue versus lab mice (Mus musculus) that form scar tissue, identifying secreted factors from activated...
KEY FINDING: Acomys macrophages exhibit a muted inflammatory profile compared to Mus macrophages and secrete factors that antagonize collagen production and drive matrix remodeling.
The Journal of Spinal Cord Medicine, 2016 • March 1, 2016
The study aimed to characterize the consistency of preventive skin care during annual evaluations for Veterans with SCI to identify strategies to promote PrU prevention care actively. The results indi...
KEY FINDING: Veterans received an average of 75.5% of applicable skin health elements during annual evaluations.