Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 131-140 of 158 results
BMC Genomics, 2017 • November 21, 2017
This meta-analysis compares gene expression profiles in response to wounding across different tissues and species. The study identifies genes with significant expression changes after wounding, compar...
KEY FINDING: Transcriptomic responses in early wound healing phases showed little consistency between tissues.
British Journal of Dermatology, 2019 • January 1, 2019
This study presents an ex vivo RNA trans-splicing-based therapeutic approach to correct the phenotype of generalized severe epidermolysis bullosa simplex (EBS-gen sev). The researchers stably transduc...
KEY FINDING: Transplanted skin equivalents generated from trans-splicing-corrected patient keratinocytes showed a stable and blister-free epidermis.
Scientific Reports, 2018 • September 12, 2018
The study demonstrates that low-dose calcipotriol can induce the expression of cathelicidin, enhance wound closure, and increase local antimicrobial defense in RDEB keratinocytes in vitro. A single-pa...
KEY FINDING: Calcipotriol treatment enhanced wound closure in RDEB cell monolayers, with up to a 2-fold increase observed in scratch closure rates.
ADVANCES IN WOUND CARE, 2020 • May 1, 2020
This study analyzes differential protein abundance of PU tissue from SCI patients using high-throughput protein identification and quantification by TMT followed by LC-MS/MS. The study identified 76 p...
KEY FINDING: The study identified 76 proteins with differences in abundance between PU and control tissue.
International Journal of Molecular Sciences, 2020 • October 21, 2020
This study investigates the therapeutic role of irisin/FNDC5 in a rat model of third-degree burn, focusing on burn-related neuropathy and its impact on pain, paresthesia, and muscle weakness. The rese...
KEY FINDING: Burn injury results in FNDC5/irisin downregulation in both the dorsal and ventral horns and decreased irisin levels in the CSF, even after wound healing.
Journal of Biological Engineering, 2020 • November 5, 2020
This study was designed to develop hybrid fiber mat compose of Ch, PVA and silk through co-electrospining process to evaluate their synergic effect on wound healing process. The Ch-PVA + Silk hybrid f...
KEY FINDING: The Ch-PVA + Silk hybrid fiber prominently showed superior mechanical properties and desire swelling as well as hydrophilic microenvironment to those of pure PVA and Ch-PVA fibers.
TheScientificWorldJOURNAL, 2006 • May 5, 2006
The review explores the regenerative capabilities of axolotls, focusing on limb regeneration and its similarities to development and wound healing. It emphasizes the biphasic nature of regeneration, t...
KEY FINDING: Limb regeneration is a biphasic process involving a preparation phase (similar to wound healing) and a redevelopment phase (similar to development).
Healthcare, 2024 • December 22, 2024
Pressure injuries are a significant challenge in healthcare, leading to complications like infections, increased care needs, and prolonged rehabilitation, impacting patients physically and psychologic...
KEY FINDING: The study included 176 patients with clinically diagnosed pressure ulcers, with 28.52% of cases as stage III and 35.57% as stage IV.
Dermatol Ther (Heidelb), 2025 • January 24, 2025
This study evaluated the rate of infections in patients with psoriasis and spinal cord injuries treated with systemic immunosuppressants over a 5-year period. The results showed that methotrexate was ...
KEY FINDING: Patients with SCI treated with MTX had higher infection rates compared to those treated with biologics.
Nursing Research and Practice, 2013 • March 6, 2013
This study aimed to investigate pressure relieving behaviors in individuals with SCI during computer use and to assess the impact of an adapted computer-based activity involving forward reaching on in...
KEY FINDING: The majority of movements participants performed during normal computer use yielded less than a 25% reduction in interface pressure compared to normal sitting, indicating low effectiveness for pressure relief.