Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 121-130 of 138 results
Annals of Rehabilitation Medicine, 2011 • October 1, 2011
This study investigated the impact of spinal cord injury (SCI) on colonic contractility and muscarinic receptor subtypes in rats. The researchers aimed to determine how SCI-induced changes in M2 and M...
KEY FINDING: SCI rats showed an increased response to Ach in the proximal colon compared to control rats, indicating altered contractility after SCI.
CNS Neurosci Ther, 2024 • January 7, 2024
This study investigated the role of EphB2 in the basolateral amygdala (BLA) in the induction and maintenance of visceral hypersensitivity induced by water avoidance stress (WAS) in rats. The findings ...
KEY FINDING: EphB2 expression was increased in the BLA of rats subjected to water avoidance stress (WAS), indicating its involvement in stress-induced visceral hypersensitivity.
Antioxidants, 2022 • November 12, 2022
The study investigated the expression of H2S-metabolizing enzymes in intestinal biopsies from healthy individuals and IBD patients, across different age groups. Immunohistochemical staining was used t...
KEY FINDING: Healthy adults showed a trend towards lower expression of H2S-metabolizing enzymes compared to healthy children, indicating an age-related decrease.
J Korean Med Sci, 2006 • January 1, 2006
This retrospective study analyzed abdominal ultrasound results of 500 SCI patients to identify abdominal organ abnormalities. The study found a high incidence of abnormalities, including liver, bladde...
KEY FINDING: Abnormal sonographic findings were observed in 45.2% of the 500 patients.
J Spinal Cord Med, 2009 • August 1, 2009
This study investigated the incidence of colonoscopic lesions in patients with spinal cord injury (SCI) compared to a control group. The results showed that patients with SCI had a similar incidence o...
KEY FINDING: Colonic lesions were observed in 52% of patients with SCI and in 41.5% of control patients, with no significant difference between the two groups.
J Spinal Cord Med, 2008 • January 1, 2008
The study demonstrated that transanal irrigation is effective in reducing constipation and improving anal continence in SCI patients, which leads to a better quality of life. Although several factors ...
KEY FINDING: The study found that transanal irrigation significantly reduced the severity of bowel dysfunction symptoms, including constipation and fecal incontinence, and improved the symptom-related quality of life in patients with SCI.
Exp Neurol, 2020 • January 1, 2020
This review addresses how SCI changes the physiological interplay between the spinal cord, the gut and the immune system. A suspected culprit in causing many of the pathological manifestations of impa...
KEY FINDING: SCI leads to gut dysbiosis, characterized by changes in the composition and abundance of gut bacteria, such as a decrease in Bacteroidales and an increase in Clostridiales.
Spinal Cord Series and Cases, 2018 • January 1, 2018
The anal exam is an integral part of the International Standards for Neurologic Classification of Spinal Cord Injury (ISNCSCI), but its importance has been debated. Previnaire emphasizes the importanc...
KEY FINDING: The ISNCSCI has undergone repeated modifications to improve accuracy and address difficulties in initial assessments, highlighting the complexity of neurological classification.
BioMed Research International, 2017 • August 30, 2017
This study investigated the relationship between liver adiposity, measured by MRI, and metabolic profile in men with chronic spinal cord injury (SCI). The results showed that increased liver fat was a...
KEY FINDING: Fat signal fraction (FSF) in the liver was positively related to triglycerides (TG), non-HDL-C, fasting glucose, and HbA1c, indicating a link between liver fat and poorer lipid and glucose control.
BMC Gastroenterology, 2018 • September 3, 2018
This study evaluates the use of vedolizumab in Austrian pediatric patients with IBD who had previously failed TNF-α antagonist treatment. The results suggest that vedolizumab can be an effective treat...
KEY FINDING: In the UC group, complete clinical remission was achieved at weeks 2, 6, and 14 in 2/5, 1/5 and 1/5 patients respectively; partial response was observed in one patient at week 2.