Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 111-120 of 138 results
Frontiers in Cellular Neuroscience, 2022 • May 4, 2022
This study investigated the therapeutic potential of ursolic acid (UA) in treating spinal cord injury (SCI) in mice, focusing on its impact on gut microbiota and metabolic changes. The research demons...
KEY FINDING: UA treatment increased body weight and soleus muscle weight of SCI mice, suggesting improved motor function.
JHEOR, 2018 • January 1, 2018
This study evaluated the cost-effectiveness of transanal irrigation (TAI) compared to standard bowel care (SBC) for managing neurogenic bowel dysfunction (NBD) in Japanese patients with spinal cord in...
KEY FINDING: The model predicts a lifetime incremental cost of TAI to be 3 198 687 yen compared with SBC.
J Spinal Cord Med, 2007 • January 1, 2007
This case series reports on 3 patients with C4 ASIA A tetraplegia who developed postoperative gastroparesis and autonomic hyperreflexia after undergoing elective abdominal surgery. The study found tha...
KEY FINDING: Gastroparesis occurred after abdominal surgery in 3 patients with C4 ASIA A tetraplegia, possibly due to autonomic hyperreflexia caused by postoperative pain.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
This study evaluated the effectiveness of pulsed irrigation enhanced evacuation (PIEE) versus polyethylene glycol-electrolyte lavage solution (PEG) for bowel preparation prior to colonoscopy in indivi...
KEY FINDING: Patients with SCI who received PIEE tended to have lower Ottawa scores and a higher percentage of acceptable preparations than did those who received PEG; however, the results were not statistically different.
Topics in Spinal Cord Injury Rehabilitation, 2019 • December 12, 2018
This retrospective study examined patients with SCI who underwent colostomy to manage bowel dysfunction, comparing those who chose it early versus later after their injury. The study found that early ...
KEY FINDING: Patients choosing early colostomy prioritize reducing reliance on caregivers and increasing independence, while those choosing it later do so to resolve existing bowel care problems.
BioMed Research International, 2019 • June 2, 2019
The study investigates the therapeutic potential of nAG protein in a rat model of liver fibrosis induced by carbon tetrachloride (CCL4). Results showed that nAG treatment significantly reduced serum l...
KEY FINDING: CCL4 treatment significantly increased serum levels of hyaluronic acid, PDGF-AB, TIMP-1, laminin, procollagen III N-terminal peptide, and collagen IV-alpha 1 chain.
Disease Markers, 2022 • October 4, 2022
This work provides a systems perspective to study the relationship between Chinese medicines and diseases. The therapeutic efficacy of XCHD on HF was the sum of multitarget and multi-approach effects fro...
KEY FINDING: 164 potential active compounds from XCHD were screened to act on 95 HF-related targets.
Spinal Cord, 2018 • March 1, 2018
The study compared transdermal administration of neostigmine/glycopyrrolate via iontophoresis to intravenous administration for bowel evacuation in spinal cord injury patients. Transdermal delivery re...
KEY FINDING: Transdermal administration of neostigmine/glycopyrrolate by iontophoresis appears to be a practical, safe, and effective approach to induce bowel evacuation in individuals with spinal cord injury.
Nature Communications, 2024 • December 8, 2024
The study identifies SCM-198 as a potential therapeutic agent for advanced acute liver failure (ALF). SCM-198 demonstrates a remarkable 100% survival rate in murine ALF models, even when administered ...
KEY FINDING: SCM-198 treatment resulted in a 100% survival rate in murine ALF models, even when administered 24 hours after ALF was established.
BioMed Research International, 2017 • November 16, 2017
This study investigates the therapeutic effects of abdominal manual therapy (AMT) on bowel dysfunction after spinal cord injury (SCI), focusing on interstitial cells of Cajal (ICCs) and c-kit expressi...
KEY FINDING: AMT significantly increased weight, shortened time to defecation, increased feces amounts, and improved fecal pellet traits and colon histology in SCI rats.