Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 211-220 of 1,651 results
Mediators of Inflammation, 2023 • March 10, 2023
This study investigates the mechanism by which SET8 regulates the Keap1/Nrf2/ARE signaling pathway to influence astrocyte autophagy and promote motor function recovery after spinal cord injury (SCI) i...
KEY FINDING: Overexpression of SET8 upregulates H4K20me1 enrichment in Keap1, inhibiting Keap1 expression and activating the Nrf2-ARE signaling pathway.
International Journal of Molecular Sciences, 2020 • September 7, 2020
This study investigates the mechanisms by which 2 Hz electroacupuncture (EA) alleviates neuropathic pain in spared nerve injury (SNI) rats, focusing on the spinal BDNF/TrκB signaling pathway. The resu...
KEY FINDING: 2 Hz EA significantly down-regulated the levels of BDNF and TrκB mRNA and protein expression in the spinal cord of SNI rats, along with ameliorating mechanical hypersensitivity.
International Journal of Molecular Sciences, 2020 • January 31, 2020
The study demonstrates that Syt-1 plays a role in the development of neuropathic pain. Electroacupuncture can alleviate neuropathic pain, possibly by suppressing Syt-1 protein expression in the spinal...
KEY FINDING: Syt-1 antibody blockade and siRNA silencing increased pain thresholds in SNI rats.
Cells, 2019 • December 6, 2019
This study investigates the therapeutic potential of dabrafenib, a B-RAFV600E inhibitor, in attenuating RIPK3-mediated necroptosis and promoting functional recovery after spinal cord injury (SCI) in a...
KEY FINDING: Dabrafenib administration significantly inhibited RIPK3-mediated necroptosis in the injured spinal cord, reducing the expression of RIPK3 and phosphorylated MLKL (pMLKL).
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
Skeletal muscle mitochondrial activity is reduced by ∼50–60% after SCI, resulting in impaired energy expenditure, glucose utilization and insulin sensitivity. Near infra-red spectroscopy (NIRS) is a n...
KEY FINDING: Only four participants produced data with accepted rate constants of 0.002–0.013 s−1 and r2 of 0.71–0.87.
Front. Mol. Neurosci., 2020 • January 10, 2020
The study explored the relationship between tsRNAs and SCI using next-generation sequencing, bioinformatics, qRT-PCR, and luciferase reporter assay. The researchers identified dysregulated expression ...
KEY FINDING: 297 differentially expressed tsRNAs were identified in rats' spinal cord 1 day after contusion. 155 tsRNAs were significantly differentially expressed: 91 up-regulated, 64 down-regulated (fold change > 1.5; P < 0.05).
International Journal of Molecular Sciences, 2019 • November 27, 2019
The study aimed to investigate gene expression changes related to cell cycle activation in patients with spinal cord injury (SCI) and to further evaluate the difference between the upper and lower limb...
KEY FINDING: Cell proliferation was significantly increased in the upper limbs of SCI patients compared to the lower limbs and healthy subjects.
J Cell Mol Med, 2020 • May 1, 2020
This study demonstrates that polydatin (PD) enhances the neuronal differentiation of bone marrow mesenchymal stem cells (BMSCs) both in vitro and in vivo, particularly promoting their differentiation ...
KEY FINDING: PD markedly facilitated BMSC differentiation into neuron-like cells by activating the Nrf2 pathway and increased the expression of neuronal markers in the transplanted BMSCs at the injured spinal cord sites.
AGING, 2021 • May 6, 2021
This study used RNA-seq to understand and identify DEGs in SCI rats fed a KD and then examine which biological signalling pathways can explain the protective effects of the KD diet on SCI rats. KD sig...
KEY FINDING: A ketogenic diet significantly improved the steroid anabolic pathway in rats with spinal cord injury.
Experimental & Molecular Medicine, 2020 • December 14, 2020
This study investigates the potential of Wnt5a to enhance neural stem cell (NSC) transplantation for spinal cord injury (SCI) repair. The research demonstrates that Wnt5a promotes NSC differentiation ...
KEY FINDING: Wnt5a and miRNA200b-3p promote NSC differentiation into neurons, with Wnt5a upregulating miRNA200b-3p expression through the MAPK/JNK pathway.