Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 11-20 of 1,651 results
Int. J. Mol. Sci., 2023 • April 11, 2023
The study demonstrates an altered profile of cytokine-producer T cells in patients with chronic SCI, with notable changes throughout the course of the disease. Significant variations in cytokine produ...
KEY FINDING: Patients with late-chronic SCI (SCI-LCP) exhibit a significant increase in the spontaneous expression of IL-10 by CD4 cells in comparison to healthy controls (HC) and SCI-SP.
J. Pers. Med., 2023 • April 2, 2023
This study investigates plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation, in patients with chronic spinal cord injury (SCI) stratified by time since injury. The results demonstra...
KEY FINDING: Patients with SCI had significantly higher plasma levels of MDA than healthy control subjects.
Glia, 2023 • September 1, 2023
This study demonstrates that the injured spinal cord remains remarkably dynamic for months after injury, exhibiting continuous myelin repair and concurrent demyelination. It identifies that glutamater...
KEY FINDING: New myelin generation peaks at 3 months post-injury but continues for at least 6 months after SCI, indicating a prolonged remyelination response.
Top Spinal Cord Inj Rehabil, 2023 • April 1, 2023
This study investigated the differential expression of vascular-related miRNAs in circulating endothelial microvesicles (EMVs) in adults with spinal cord injury (SCI). The study found that adults with...
KEY FINDING: Circulating EMV levels were significantly higher in adults with SCI compared to uninjured adults.
Clinical and Translational Medicine, 2023 • May 21, 2023
This study investigates the therapeutic effects of intravenous delivery of small extracellular vesicles (sEVs) derived from human mesenchymal stem/stromal cells (MSC) on body growth and motor recovery...
KEY FINDING: Intravenous delivery of human and rat MSC-sEVs improved functional motor recovery after SCI and restored normal body growth in young adult SCI rats.
Journal of Inflammation Research, 2023 • June 13, 2023
This review highlights the significant role of non-coding RNAs (ncRNAs) in regulating neuroinflammation (NI) following spinal cord injury (SCI), which subsequently influences the development of neurop...
KEY FINDING: miRNAs regulate inflammation after SCI by influencing microglia-mediated inflammation, with some miRNAs like miR-137-3p reducing pro-inflammatory factors by targeting NeuroD1. NF-κB-dependent inflammation is also modulated by miRNAs, impacting neuropathic nociceptive hyperalgesia.
Frontiers in Medicine, 2023 • June 8, 2023
This study aimed to explore the molecular events related to bone defect progression using bioinformatic analysis of transcriptome data and experimental validation. Key findings include the identificat...
KEY FINDING: The study identified 2057, 827, and 1,024 DEGs at 7, 14, and 21 days post injury, respectively, in critical size defects (CSD) compared to non-critical size defects (NCSD).
J South Med Univ, 2023 • June 1, 2023
This study investigates the potential of Acetylcorynoline (Ace) to promote functional recovery after spinal cord injury (SCI) in rats by modulating the EGFR/MAPK signaling pathway to inhibit microglia...
KEY FINDING: Ace treatment significantly increased the BBB score, reduced the area of spinal cord injury, and lowered the number of activated microglia cells and the levels of pro-inflammatory cytokines.
Spinal Cord Series and Cases, 2023 • June 27, 2023
The study compared oxidative stress and antioxidant responses to high-intensity arm cranking exercise in individuals with SCI and able-bodied controls. SCI participants exhibited lower baseline levels...
KEY FINDING: SCI participants had lower baseline levels of certain antioxidants (α-carotene, β-carotene) and creatinine compared to controls.
Journal of Traditional Chinese Medicine, 2023 • December 14, 2022
This study aimed to investigate the analgesic effects of Chinese Tuina on neuropathic pain in rats by examining synaptic structure remodeling in the spinal cord dorsal horn (SCDH). The results showed ...
KEY FINDING: Tuina and MK-801 (an NR2B antagonist) reversed CCI-induced changes in motor function and reduced mechanical and cold allodynia in rats.