Genetics Research

KEY FINDING: SIRT2 expression and deacetylase activity increase within motoneurons after axotomy, suggesting a role in motor regeneration.

KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.

KEY FINDING: sEVs showed no significant difference in size or concentration between healthy and lipedema patients.

KEY FINDING: Upregulation of Lin28a in transgenic mice induces significant long-distance regeneration of corticospinal axons and the optic nerve in adult mice.

KEY FINDING: The majority of brainstem cell types in SOD1 mutant mice, including astrocytes, oligodendrocytes, microglia, and neurons, showed significant transcriptomic alterations.

KEY FINDING: In vivo neural reprogramming has achieved impressive progress, ranging from generation of diverse glia-converted neurons in multiple CNS regions to functional improvements for certain neurological conditions.

KEY FINDING: Several miRNAs are aberrantly expressed in rats after spinal cord ischemia-reperfusion injury (SCIRI). At 24 hours, 13 miRNAs were aberrantly expressed, including 12 upregulated miRNAs and 1 downregulated miRNA.

KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.

KEY FINDING: IL-20 and its receptors are expressed in astrocytes, oligodendrocytes, and microglia in the spinal cord after SCI in rats.

KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.