Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,591-1,600 of 1,651 results
J. Vis. Exp., 2012 • February 16, 2012
The spinal cordslice is an ideal recipient tissue for studying NPC ex vivo behaviours, post-transplantation, because the cytoarchitectonic tissue organization is well preserved within these cultures T...
KEY FINDING: NPCs showed highly directed cell migration towards the cathode when exposed to a range of physiological EFs.
Front. Neurosci., 2025 • January 7, 2025
Mitochondria, supplying most ATP through oxidative phosphorylation, produce mtROS byproducts that can act as molecular signals or cause cell death. Maintaining a healthy mitochondrial state involves m...
KEY FINDING: Mitochondrial protein acetylation, particularly through enzymes like GCN5L1 and Sirt3, plays a significant role in neuronal activity and the pathophysiology of cerebral injury. Sirt3, for example, regulates processes such as mPTP opening, mitochondrial dynamics, and mitophagy, protecting mitochondrial function and preventing neuronal death in ischemic stroke.
Biomedical Optics Express, 2011 • July 27, 2011
This study demonstrates the application of femtosecond lasers for precise ablation of melanocytes in Xenopus laevis tadpoles. It showcases the laser's ability to mark, pattern, and ablate these cells ...
KEY FINDING: Femtosecond lasers can be used to precisely ablate melanocytes in Xenopus laevis tadpoles, enabling controlled studies of cell migration and regeneration.
J Control Release, 2015 • April 28, 2015
This study introduces a novel method of delivering lentiviruses to the spinal cord using macro-porous sponges inserted into the intrathecal space. This method allows for long-term, localized expressio...
KEY FINDING: Lentivirus-filled sponges inserted into the intrathecal space resulted in transgene expression within multiple cell types for 12 weeks in both intact and injured spinal cords.
International Journal of Molecular Sciences, 2022 • March 15, 2022
This review highlights the potential of sovateltide, a selective ETBRs agonist, as a therapeutic candidate for neurological disorders. Preclinical and clinical studies suggest its safety and efficacy ...
KEY FINDING: Sovateltide has shown promise in preclinical studies for treating cerebral stroke, Alzheimer's disease, spinal cord injury, and neonatal hypoxic-ischemic encephalopathy by promoting neuroprotection and neuroregeneration.
JOURNAL OF VIROLOGY, 1999 • July 1, 1999
This study demonstrates that poliovirus (PV) infection in mice leads to apoptosis in the central nervous system (CNS), contributing to the paralysis observed in poliomyelitis. Both neurovirulent and a...
KEY FINDING: PV infection causes cleavage of DNA into nucleosomes in the mouse CNS, indicating apoptosis.
eLife, 2020 • April 27, 2020
By intersecting chromatin accessibility data with single-cell transcriptomics, we find that NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to prol...
KEY FINDING: NPCs place an early priority on neuronal differentiation. Late in regeneration, the priority returns to proliferation.
Biomolecules, 2022 • March 12, 2022
This study identifies three L1 antagonistic mimetics—anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol—that inhibit the migration of cultured tumor cells in an L1-dependent manner. The mimetics ...
KEY FINDING: Anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol competitively inhibit antibody 324 binding to L1, suggesting they interfere with L1's function.
Stem Cell Rev and Rep, 2014 • May 8, 2014
This study investigates the guided migration of embryonic stem cell (ESC) derived presumptive motor neurons in an applied electric field (EF). The results showed that neural precursors migrated toward...
KEY FINDING: Neural precursors migrated toward the cathode pole of applied electric fields.
Gene, 2011 • July 1, 2011
The study demonstrates that miR-146a regulates cartilage-degrading proteases and pain-associated inflammatory molecules in knee joint tissues. MiR-146a functions in an anti-catabolic manner by antagon...
KEY FINDING: MiR-146a suppresses extracellular matrix proteins in human knee chondrocytes and regulates inflammatory cytokines in human knee joint synovial cells.