Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,601-1,610 of 1,651 results
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
Dev Cell, 2021 • March 8, 2021
This study identified an essential EMT-driving gene regulatory network that regulates differential regenerative capacity between mammals and zebrafish after SC injury. At the center of glial bridging ...
KEY FINDING: Pro-regenerative zebrafish glia activate an epithelial-to-mesenchymal transition (EMT) gene program, distinguishing them from mammalian glia.
Exp Neurol, 2016 • September 1, 2016
The study examined whether eliminating myelin-associated inhibitors or activating intrinsic growth pathways could enhance NT-3-mediated regeneration of sensory axons through the dorsal root entry zone...
KEY FINDING: Loss of myelin inhibitory proteins showed modest enhancement of sensory axon regeneration.
International Medical Case Reports Journal, 2025 • January 4, 2025
This case report describes a 68-year-old male diagnosed with TTR-FAP with an uncommon presentation of spinal cord damage. The patient's symptoms included progressive limb weakness and numbness, autono...
KEY FINDING: The patient presented with a rare manifestation of TTR-FAP, specifically spinal cord damage, which is not commonly associated with the c.148G>A (p.Val50Met) mutation.
Life, 2023 • December 20, 2022
Traumatic SCI induces complex pathological processes, leading to physical impairment and psychological devastation. The two phases are primary mechanical damage and secondary injury. This involves vas...
KEY FINDING: Neurotrophic factors like NGF, BDNF, and NT-3 are involved in the nervous system's development and maintenance, helping to rebalance the microenvironment after SCI. Mature NGF is neuroprotective, promoting neuronal differentiation and survival. BDNF has neuroprotective and growth-promoting effects, promoting regeneration and formation of damaged axons.
Neural Regen Res, 2020 • October 18, 2019
This study investigates the spatiotemporal expression of LIFR in normal and neural tube defect (NTD) embryos to understand its role in NTD pathogenesis. A rat model of spina bifida aperta (SBA) was us...
KEY FINDING: LIFR protein and mRNA expression in the spinal cords of normal rat embryos increased with embryonic development from E11 to E17.
International Journal of Nanomedicine, 2020 • January 21, 2020
The study aimed to enhance Schwann cell (SC) migration across astrocyte boundaries in vitro using chondroitinase ABC (ChABC)-loaded superparamagnetic nanoparticles (SPIONs) and a magnetic field (MF) t...
KEY FINDING: Magnetofection with ChABC/PEI-SPIONs significantly increased ChABC expression in SCs, which degrades chondroitin sulfate proteoglycans (CSPGs).
Stem Cell Reports, 2014 • August 7, 2014
This study compares TALENs and CRISPRs for gene knockout in axolotls, finding CRISPRs to be more efficient and less toxic. Deletion of Sox2, a key neural stem cell gene, was achieved using CRISPR tech...
KEY FINDING: CRISPRs are more effective and less toxic than TALENs for gene knockout in axolotls, achieving higher knockout penetrance.
Scientific Reports, 2017 • September 20, 2017
The study demonstrates that skeletal muscle fibers release exosomes, extending previous research on exosomes from myoblasts and myotubes. These exosomes contain microRNAs and can be taken up by recipi...
KEY FINDING: Skeletal muscle fibers release exosomes containing proteins and miRNAs.
Frontiers in Molecular Neuroscience, 2024 • July 15, 2024
This review summarizes recent advancements in understanding the roles of circRNAs in nerve injury and repair, focusing on their involvement in signaling pathways and gene regulatory networks pertinent...
KEY FINDING: CircRNAs play a role in peripheral nerve injury (PNI), with specific circRNAs like circ-Ankib1 and circ-Spidr influencing Schwann cell proliferation and axon regeneration.