Genetics Research

KEY FINDING: Array-based comparative genomic hybridization can be used to diagnose tethered spinal cord syndrome.

KEY FINDING: Rostral cervical spinal cord neurites prefer to grow on rostral diaphragm membranes, while caudal cervical neurites prefer caudal diaphragm membranes.

KEY FINDING: Early-generated ATRA performs three essential functions: (1) activation of genes that control hindbrain and spinal cord patterning; (2) repression of Fgf8 in the heart field and caudal progenitors; and (3) actions that stimulate invagination of the optic vesicle to form the optic cup.

KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.

KEY FINDING: Axolotl embryos can completely regenerate amputated tails in 7 days without feeding, making them an efficient model for regeneration studies.

KEY FINDING: The AAVS1 locus in human cells is suitable for integrating conditional reporters for reliable transgene expression during lineage tracing.

KEY FINDING: The protocol demonstrates fragmented DNA to a length of approximately 200-1000 bp following sonication.

KEY FINDING: MiR-449a is down-regulated in osteosarcoma and suppresses cell proliferation by targeting CCNB1.

KEY FINDING: Publications in this field have grown rapidly in the past 2 decades and are expected to keep increasing.

KEY FINDING: Netrin-1 acts as a chemorepellent for developing DRG axons, preventing them from projecting aberrantly toward the ventral spinal cord and ensuring correct projection toward the DREZ.