Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,621-1,630 of 1,651 results
Cells, 2021 • April 10, 2021
This study demonstrates that hair-follicle-associated pluripotent (HAP) stem cells can be efficiently differentiated into dopaminergic neurons in vitro. These HAP stem cell-derived dopaminergic neuron...
KEY FINDING: Mouse HAP stem cells can efficiently differentiate into dopaminergic neurons when cultured in neural-induction medium.
J Korean Neurosurg Soc, 2010 • January 1, 2010
The study aimed to investigate the molecular biologic characteristics of primary and recurrent herniated discs to understand the similarities and differences in their gene expression profiles. The res...
KEY FINDING: mRNA gene expression of recurrent disc cells showed increased expression of aggrecan, type I collagen, type II collagen, Sox-9, osteocalcin, and alkaline phosphatase compared to primary herniated lumbar disc cells.
Journal of Orthopaedic Surgery and Research, 2016 • September 5, 2016
This study aimed to identify key molecular pathways involved in spinal cord injury (SCI) by analyzing gene expression profiles in rats at different time points after injury. The analysis revealed 416 ...
KEY FINDING: A total of 416 genes showed significant differential expression at all time points after SCI, suggesting their consistent involvement in the injury response.
J Cell Physiol, 2015 • July 1, 2015
This study investigates the migration of Schwann cells in electric fields (EFs), finding that they migrate towards the anode, with increased directedness and displacement at higher EF strengths. RNA s...
KEY FINDING: Schwann cells migrate towards the anode in an applied electric field, and the directedness and displacement of migration increase with the strength of the electric field.
iScience, 2021 • January 22, 2021
This study uses genome-scale CRISPR screening in hPSCs to identify genes that prevent lineage specification, termed lineage-specification preventing genes (LPGs). The screening revealed that LPGs are ...
KEY FINDING: A genome-scale CRISPR screen in hPSCs identified lineage-specification preventing genes (LPGs) that, when knocked out, cause the cells to differentiate into specific germ layers.
Neural Development, 2012 • April 26, 2012
This study investigates the role of Sox2+ cells in spinal cord regeneration in Xenopus laevis tadpoles after tail amputation and spinal cord transection. The results demonstrate that spinal cord injur...
KEY FINDING: Tail amputation increases Sox2 mRNA and protein levels in the spinal cord, lateral line, and olfactory epithelium, indicating a systemic response to tissue injury.
Frontiers in Neurology, 2022 • May 20, 2022
Spinal Cord Injury (SCI) is a serious condition with limited effective treatments, often resulting in inflammation, apoptosis, autophagy, and oxidative stress. The mTOR signaling pathway plays a key r...
KEY FINDING: Quercetin has antioxidant and anti-inflammatory properties, promotes autophagy, and inhibits apoptosis, making it a potential drug for SCI.
Neural Regeneration Research, 2025 • July 29, 2024
This review examines the therapeutic strategies targeting the C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 axis, along with the regenerative and repair mechanisms linking the axis to sp...
KEY FINDING: The CCL2/CCR2 axis recruits immune cells to the injury site, stimulating microglia and macrophages, which exacerbates the inflammatory response and nerve damage, worsening SCI.
Lipids in Health and Disease, 2023 • October 2, 2023
This study identified a novel frameshift insertion in the LDLR gene and several variants in the APOB gene in a Chinese family with familial hypercholesterolemia. The cumulative effect of these genetic...
KEY FINDING: A novel frameshift insertion (c.497delinsGGATCCCCCAGCTGCATCCCCCAG: p. Ala166fs) was identified in the LDLR gene, preventing proper expression of LDLR on the cell membrane.
Journal of Biological Chemistry, 2010 • January 8, 2010
The study identifies FM19G11 as a novel HIF inhibitor that selectively targets HIF proteins without significant cytotoxicity. FM19G11 promotes oligodendrocyte differentiation under hypoxic conditions ...
KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.