Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 171-180 of 1,651 results
Cell Biosci, 2021 • January 1, 2021
A series of pathophysiological changes occur after SCI. The primary injury is related to the destruction of axons and neurons. The secondary injury is caused by nerve inflammation, which directly or i...
KEY FINDING: MSCs can regulate macrophage polarization by secreting soluble proteins, including ILs and chemokines, which ultimately relieve SCI.
Molecular Pain, 2021 • February 9, 2021
This study explores the impact of different spinal cord stimulation (SCS) parameters on microglial activation in a rat model of neuropathic pain. The researchers compared differential target multiplex...
KEY FINDING: DTMP shows the highest significant correlations to expression levels found in healthy animals across all microglial activation transcriptomes, indicating a modulation towards a healthy state.
Translational Neuroscience, 2021 • January 27, 2021
This study investigates the role of lncRNA H19 and miR-370-3p in spinal cord injury (SCI) using an in vitro model. The results indicate that inhibiting lncRNA H19 can mitigate spinal neuron apoptosis,...
KEY FINDING: SCI leads to increased lncRNA H19 and decreased miR-370-3p expression.
Front. Mol. Neurosci., 2021 • February 25, 2021
The study demonstrates that NL1 expression is upregulated in excitatory neurons of the spinal dorsal horn in a mouse model of neuropathic pain (SNI). Reducing NL1 levels in excitatory neurons through ...
KEY FINDING: NL1 is upregulated in the L4–L6 spinal dorsal horn in Vglut2-cre+/−mouse subjected to spared nerve injury (SNI).
Frontiers in Medicine, 2021 • March 4, 2021
The study investigates the role of ZBTB20 in itch sensation using PN-ZB20KO mice and gene silencing techniques. It found that ZBTB20 is involved in both histamine- and non-histamine-dependent itch. ZB...
KEY FINDING: Histamine-dependent and non-histamine-dependent itch behaviors were significantly diminished in PN-ZB20KO mice.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This study investigates the effects of chondroitinase ABC (ChABC) on axon regeneration and retrograde apoptosis signaling in lampreys after spinal cord injury (SCI). The researchers found that ChABC t...
KEY FINDING: ChABC treatment reduces the distance between axon tips and the injury site early after spinal cord injury, suggesting it inhibits axon retraction or promotes early regrowth.
Molecular Pain, 2021 • March 9, 2021
The study examined whole blood gene expression in individuals with chronic SCI compared to able-bodied individuals, focusing on differences based on pain status and pain type. Results showed distinct ...
KEY FINDING: Participants with SCI who reported pain had 468 differentially expressed (DE) genes compared to able-bodied (AB) individuals, while those without pain had 564 DE genes.
J. Clin. Med., 2021 • April 9, 2021
This systematic review aimed to assess the composition of the gut microbiota in patients with SCI or MS compared to healthy controls, considering the potential roles of neurogenic bowel function, diet...
KEY FINDING: The review found that alpha diversity in chronic SCI patients might be lower compared to healthy controls, while alpha diversity in MS patients might be similar or lower.
PLoS ONE, 2021 • May 6, 2021
This study investigated the role of the CHRFAM7AΔ2bp variant in inflammation following spinal cord injury (SCI) in 45 patients, stratified by injury severity. Results indicated that the Δ2bp variant i...
KEY FINDING: In severe SCI patients, carriers of the Δ2bp variant showed higher levels of circulating inflammatory mediators compared to non-carriers.
Cureus, 2021 • April 27, 2021
This article reviews the current literature on neurogenic heterotopic ossification (NHO), a condition characterized by pathological bone formation in soft tissues following spinal cord or brain injury...
KEY FINDING: NHO prevalence in SCI patients ranges from 10% to 53%, with lower rates in pediatric patients.