Genetics Research

KEY FINDING: Treated pigs showed increased PTIBS scores, indicating improved motor function in hind limbs, and demonstrated vocal and motor reactions during skin pinch tests.

KEY FINDING: TRESK expression is upregulated in both dorsal and ventral neurons of the spinal cord following SCI, with significant increases observed at acute time points (6, 24, and 48 hours) post-injury.

KEY FINDING: Knockdown of DOK3 in microglial cells dramatically reduced the levels of inflammatory factors, suggesting that DOK3 regulates the release of a subset of inflammatory mediators in microglia under physiologic conditions.

KEY FINDING: The combination of USW and HUC-MSCs significantly improved motor function in SCI rats, with USW playing a more prominent role.

KEY FINDING: Treadmill exercise reduces the lesion cavity size and the number of ED1-positive cells (macrophages) in the injured spinal cord.

KEY FINDING: Chronic SCI patients exhibit impaired circulating monocyte function, including diminished TLR4 expression, increased LPS-induced TNF-α production, and defective phagocytosis.

KEY FINDING: Exosomes derived from MSCs have anti-inflammatory effects, reducing pro-inflammatory cytokines and promoting an anti-inflammatory environment conducive to functional recovery after SCI.

KEY FINDING: There is an asymmetric gene expression induced by the injury, with a higher regulation in the rostral segment of genes involved in ECM remodeling, adhesion and cell migration.

KEY FINDING: Microglia were rapidly lost in the lesion core, while blood-borne macrophages dominated, showing an intermediate activation phenotype.

KEY FINDING: A 50 kdyne contusion SCI in young male mice resulted in decreased body mass and loss of mass in plantaris and gastrocnemius muscles.