Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 241-250 of 1,651 results
Scientific Reports, 2015 • July 30, 2015
This study investigates the molecular mechanisms behind post-SCI spasticity, focusing on the role of mRNA editing and ADAR2. The research demonstrates that SCI-induced inflammation leads to down-regul...
KEY FINDING: SCI leads to a decrease in mRNA editing of 5-HT2CR, specifically at site D, and Kv1.1 channel due to down-regulation of ADAR2 expression.
Neurobiol Dis., 2015 • November 1, 2015
This study investigates the role of Protease Activated Receptor 2 (PAR2) in inflammatory astrogliosis following spinal cord injury (SCI). The results demonstrate that mice lacking the PAR2 gene exhibi...
KEY FINDING: Mice lacking the PAR2 gene showed greater improvements in motor coordination and strength after spinal cord injury compared to wild type littermates.
Neural Regeneration Research, 2015 • July 1, 2015
Mitochondria play an essential role in cell signaling, differentiation, and survival, and their dysfunction is linked to diverse human diseases, including neurodegenerative diseases and central nervou...
KEY FINDING: Nuclear-encoded miRNAs can be found in mitochondria and can directly regulate mitochondrial proteins, such as miR-181c targeting cytochrome c oxidase subunit 1 (COX1).
PLOS ONE, 2015 • September 11, 2015
This study investigates the anti-inflammatory role of IL-27 in zymosan-induced peritonitis, focusing on its effects on neutrophil recruitment. The results demonstrate that IL-27 reduces neutrophil acc...
KEY FINDING: IL-27 treatment reduces neutrophil accumulation in the peritoneal cavity in a zymosan-induced peritonitis model.
PLoS ONE, 2016 • December 1, 2016
This study investigated microRNA (miR) expression profiles in paralyzed gastrocnemius muscle of rats after spinal cord injury (SCI) compared to sham-operated rats to understand the mechanisms behind m...
KEY FINDING: miRs 23a, 23b, 27b, 145, and 206, were downregulated in skeletal muscle 56 days after SCI.
Oncotarget, 2017 • December 1, 2016
This study investigates the role of macrophage migration inhibitory factor (MIF) in the inflammatory response of astrocytes following spinal cord injury. The findings demonstrate that MIF activates in...
KEY FINDING: MIF expression increases significantly after spinal cord injury and colocalizes with microglia and astrocytes.
Neuroimmunol Neuroinflamm, 2019 • January 1, 2019
This review explores the roles of microRNAs (miRNAs) in spinal cord injury (SCI) pathophysiology, focusing on how miRNAs modulate key molecular processes such as neuroplasticity, astrogliosis, neuropa...
KEY FINDING: miRNAs are deregulated after SCI and impact inflammation, oxidative stress, and apoptosis, which are crucial for progressive pathogenesis in SCI, suggesting that abnormal miRNA expression may contribute to SCI pathogenesis.
Physiol Rep, 2015 • November 1, 2015
The study examined the expression of microRNAs and myostatin in skeletal muscle of humans with spinal cord injury. It found a progressive decline in microRNA-208b and microRNA-499-5p expression after ...
KEY FINDING: Skeletal muscle expression of microRNA-208b and microRNA-499-5p progressively declined within the first year after cervical spinal cord injury in humans, with changes maintained in long-standing injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015 • May 21, 2015
This study investigates the antioxidative effects of Gua Lou Gui Zhi decoction (GLGZD) on hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma cells (PC12 cells). The results demo...
KEY FINDING: GLGZD pretreatment alleviates H2O2-induced damage in PC12 cells, as evidenced by morphological observations and increased cell viability.
Oxidative Medicine and Cellular Longevity, 2016 • January 1, 2016
The study revealed that SCI induces an increase in HDAC6 expression in vivo. This upregulation suggests a potential role for HDAC6 in the cellular response to SCI. In vitro experiments demonstrated th...
KEY FINDING: SCI increases HDAC6 expression in vivo.