Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 251-260 of 1,651 results
Neurochemical Research, 2023 • September 12, 2022
This study investigates the context-dependent effects of the complement peptide C3a on primary mouse astrocytes under different conditions: naive, after chemical ischemia, and after exposure to lipopo...
KEY FINDING: C3a down-regulated the expression of Gfap, C3 and Nes in astrocytes after ischemia, suggesting a reduction in reactive astrocyte markers in this context.
Glia, 2016 • June 1, 2016
This study investigates the protective effects of adrenergic receptor agonists, specifically epinephrine (EPI) and isoprenaline (ISO), on cellular edema induced by hypotonicity and neurotrauma in cort...
KEY FINDING: Epinephrine administration reduces hypotonicity-induced swelling of astrocytes both in vivo and in vitro.
Scientific Reports, 2016 • March 11, 2016
This study elucidates the role of miR-434-3p in regulating eIF5A1 expression and AChRs formation in a rat model of spinal cord transection (SCT). The findings demonstrate that miR-434-3p acts as a neg...
KEY FINDING: miR-434-3p directly targets eIF5A1 to negatively regulate its expression in rat skeletal muscle.
International Journal of Molecular Sciences, 2017 • January 25, 2017
This study examined the long-term effects of iNOS ablation in mice after spinal cord injury (SCI). The findings suggest that while acute iNOS inhibition may be beneficial, long-term ablation can be de...
KEY FINDING: iNOS−/− mice exhibited less preserved white and gray matter at six weeks post-SCI compared to wild-type controls.
Physiol Rep, 2017 • February 1, 2017
This study investigated the relationship between body composition and mitochondrial mass and activity in skeletal muscle biopsies from individuals with SCI. The study found that increased adipose tiss...
KEY FINDING: Citrate synthase (CS) activity, a marker of mitochondrial mass, was inversely related to %body fat, %leg fat, %trunk fat, and %android fat.
International Journal of Molecular Sciences, 2017 • February 27, 2017
This study investigated the effects of transplanting embryonic spinal cord-derived cells into injured peripheral nerves to prevent muscle atrophy. Both fetal cells (P0) and neural progenitor cells (P2...
KEY FINDING: Both fetal spinal cord cells (P0) and neural progenitor cells (P2) were able to survive in the injured peripheral nerve environment.
PLoS ONE, 2017 • March 27, 2017
The study found that loss of functional sympathetic innervation to the liver and VAT appears to favorably impact circulating TG concentrations and concentrations of total and specific subclasses of VL...
KEY FINDING: Men with SCI at or above the 4th thoracic vertebrae (T4), indicating more extensive sympathetic nervous system impairment, had significantly lower serum triglyceride (TG) concentrations compared to those with SCI at or below the 5th thoracic vertebrae (T5) and able-bodied (AB) subjects.
PLoS ONE, 2017 • March 30, 2017
The study identified clusters of adherent cells in short-term cultures from amniotic fluid cells of MMC-AF samples, which were phenotypically reminiscent of early neuroepithelium and absent in norm-AF...
KEY FINDING: A population of cells from the amniotic fluid of MMC fetuses (MMC-AF) formed adherent clusters of tightly packed cells, which were absent from the AF of normal control fetuses (norm-AF).
Neural Regeneration Research, 2015 • June 1, 2015
This study investigated the effects of hydrogen-rich saline on spinal cord injury (SCI) in rats. Hydrogen-rich saline was administered into the subarachnoid space of rats after SCI. The results showed...
KEY FINDING: Hydrogen-rich saline markedly reduced cell death in the injured spinal cord tissue compared to the control group receiving physiological saline.
ASSAY and Drug Development Technologies, 2015 • September 1, 2015
The study developed two HCA assays to investigate reactive-like changes in astrocytes: one measuring the stellation index (GFAP+ process area/cell body area) and another monitoring the expression of g...
KEY FINDING: The GFAP morphology assay is suitable for counter-screening with a Z-factor of 0.44 – 0.03.