Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 231-240 of 1,651 results
Glia, 2015 • May 1, 2015
Here we show that the thrombin receptor is an essential intrinsic suppressor of spinal cord myelination. Deletion of the gene encoding the thrombin receptor resulted in spinal cord hypermyelination, i...
KEY FINDING: PAR1 gene deletion resulted in earlier onset of spinal cord myelination and higher levels of proteolipid protein (PLP) at birth.
Scientific Reports, 2016 • September 27, 2016
This study investigates the role of HB-GAM in reversing the inhibitory effects of the CNS extracellular matrix on neural regeneration. It demonstrates that HB-GAM promotes neurite outgrowth by interac...
KEY FINDING: HB-GAM promotes neurite outgrowth on CSPG substrates, overcoming the inhibitory effects of aggrecan, neurocan, and brain-derived CSPGs.
JOURNAL OF NEUROTRAUMA, 2017 • February 1, 2017
The study found that HMGB1 is elevated systemically in persons with acute or chronic traumatic SCI. HMGB1 levels in acute SCI were significantly higher than in uninjured persons and more than two-fold...
KEY FINDING: HMGB1 levels are significantly elevated in individuals with acute SCI within 0-3 days and 4-7 days post-injury, compared to uninjured controls.
The Journal of Neuroscience, 2015 • March 11, 2015
This study investigates the role of complement C1q in neurite outgrowth in vitro and axon regeneration in vivo after spinal cord injury (SCI). The findings demonstrate that C1q increases neurite lengt...
KEY FINDING: Complement C1q increases neurite length on myelin in vitro, rescuing neurons from myelin-mediated growth inhibition.
Pain Research and Management, 2022 • July 8, 2022
This study explored the relationship between pain, bone metastasis, and cytokine expression in cancer patients treated with external radiation therapy. The research aimed to identify specific cytokine...
KEY FINDING: Radiotherapy significantly improved pain scores and quality of life in cancer patients with bone metastasis.
Cell Mol Neurobiol, 2015 • March 29, 2015
This study demonstrates that PQQ pretreatment has a protective effect in a rat model of intracerebral hemorrhage (ICH). The protective effects of PQQ include improved locomotor function, reduced hemat...
KEY FINDING: PQQ pretreatment improved locomotor function in rats after ICH, as evidenced by neurobehavioral deficit scoring.
Int. J. Mol. Sci., 2015 • April 9, 2015
This study measured serum cytokine levels in 40 acute traumatic SCI patients over 12 weeks to assess their impact on neurological outcome. The study found that specific cytokines (TNFα, IL-1β, IL-6, I...
KEY FINDING: TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission.
Mol Cell Neurosci, 2015 • September 1, 2015
This study elucidates the regulatory mechanisms governing NRG1 expression in motor neurons, demonstrating the importance of axon-target interactions and neurotrophic factors. The findings reveal that ...
KEY FINDING: Axon-target interactions regulate NRG1 mRNA expression during early development, suggesting a trophic role from the developing limb.
J Muscle Res Cell Motil, 2015 • October 1, 2015
This review focuses on the role of focal adhesion kinase (FAK), a prominent and well-studied protein that responds to changes in cellular tension. FAK has multiple roles within skeletal muscle, includ...
KEY FINDING: Changes in FAK expression and phosphorylation correlate with myoblast differentiation, muscle fiber formation, and muscle size changes due to loading and unloading.
JOURNAL OF NEUROTRAUMA, 2017 • March 15, 2017
The study investigates the role of RNA-binding protein HuR in the inflammatory response following spinal cord injury (SCI). The research demonstrates that HuR is translocated to the cytoplasm in astro...
KEY FINDING: HuR translocates to the cytoplasm of astrocytes at the site of spinal cord injury, indicating its activation in response to the trauma.