Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 331-340 of 1,651 results
Dev Dyn, 2021 • June 1, 2021
Salamanders possess remarkable regenerative abilities, and the immune system plays a crucial role in these processes. Both innate and adaptive immune components are involved, with macrophages being pa...
KEY FINDING: Macrophages are recruited to the regenerating limb and heart, contributing to ECM remodeling, clearance of cellular debris and senescent cells.
Neural Regeneration Research, 2021 • April 1, 2021
This study investigates synaptic remodeling in the mouse motor cortex following spinal cord hemi-section (SPH). The findings indicate that SPH leads to bilateral remodeling of postsynaptic dendritic s...
KEY FINDING: Spinal cord hemi-section (SPH) led to bilateral remodeling of dendritic spines in the motor cortex, with the main remodeling regions changing over time.
Glia, 2021 • May 1, 2021
This study investigates the heterogeneity of astrocyte subtypes in different brain regions and their response to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. The re...
KEY FINDING: Astrocytes exhibit significant regional heterogeneity, with distinct gene expression profiles depending on their location in the forebrain, hindbrain, or spinal cord.
Molecular Oncology, 2021 • January 24, 2021
This study benchmarks HLA genotyping on TCGA data using multiple tools to generate reliable HLA genotyping results. It finds that HLA class I genotyping is generally better than class II genotyping, w...
KEY FINDING: POLY-SOLVER, OptiType, and xHLA show high accuracy in HLA class I genotyping, with accuracies of 0.954, 0.949, and 0.937, respectively.
Neurospine, 2021 • June 1, 2021
Spinal cord injuries present with a complex series of molecular cascades that ultimately induce cell death of neurons and glia and excitotoxicity of astrocytes, limiting the effect of therapeutic inte...
KEY FINDING: RIPK1 exhibits pleiotropic effects contributing to the exacerbation of SCI and sufficient evidence supports the therapeutic utility of RIPK1 inhibitors.
Trends Neurosci., 2021 • June 1, 2021
Extracellular vesicles (EVs) play significant roles in the central nervous system (CNS), mediating both physiological and pathophysiological processes, especially after neurotrauma like spinal cord in...
KEY FINDING: EVs have functional roles in mediating neuro-glia and CNS-periphery communication after neurotrauma by regulating neuronal function, axonal regeneration and remyelination, metabolic activity, and the inflammatory milieu.
Bioactive Materials, 2021 • January 24, 2021
The study introduces a novel therapeutic approach for spinal cord injury (SCI) using a bioactive, injectable, self-healing, and anti-inflammatory hydrogel (FE@EVs) designed for the sustained release o...
KEY FINDING: The FE@EVs hydrogel effectively encapsulates and releases extracellular vesicles in the injured spinal cord, facilitating efficient integrated regulation.
G3, 2021 • March 20, 2021
The study combines high-efficiency CRISPR/Cas9 mutagenesis with functional phenotypic screening to identify genes required for spinal cord repair in adult zebrafish. Seventeen genes were targeted, and...
KEY FINDING: CRISPR/Cas9 dual-guide ribonucleic proteins (dgRNPs) can achieve selective and combinatorial mutagenesis of 17 genes at 28 target sites with efficiencies exceeding 85% in adult F0 crispants.
Bioactive Materials, 2021 • March 2, 2021
This study evaluated the function of OXR1 in SCI and developed an available carrier for delivering the OXR1 plasmid (pOXR1). The particle size of pOXR1 was compressed to 58 nm, which suggests that pOX...
KEY FINDING: OXR1 expression increases after spinal cord injury and appears to have a protective effect.
Stem Cell Research & Therapy, 2021 • April 19, 2021
This study demonstrates that exosomes derived from miR-26a-modified mesenchymal stem cells (MSCs) can effectively promote axonal regeneration and functional recovery in a rat model of spinal cord inju...
KEY FINDING: Exosomes derived from miR-26a-modified MSCs (Exos-26a) promote axonal regeneration in a rat model of spinal cord injury.