Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 321-330 of 1,651 results
PLoS ONE, 2012 • December 1, 2012
This study investigates the use of photomechanical waves (PMWs) to deliver small interfering RNAs (siRNAs) targeting intermediate filament (IF) proteins, such as GFAP and vimentin, to SCI model rats. ...
KEY FINDING: PMW-mediated delivery of siRNAs targeting GFAP and vimentin resulted in significant improvement in locomotive function from five days post-injury.
Mediators of Inflammation, 2013 • February 2, 2013
Individuals with spinal cord lesions have a higher risk for obesity and, consequently, low-grade chronic inflammation due to the accumulation of visceral fat and the subsequent increased production of...
KEY FINDING: Spinal cord injury is associated with increased serum concentrations of C-reactive protein, interleukin 6 (IL-6), and endothelin-1, suggesting a state of chronic inflammation independent of obesity.
PLoS ONE, 2013 • May 24, 2013
The study investigated chronic progressive compression of the cervical spinal cord in twy/twy mice, finding neuronal loss and increased CD11b-positive cells at the compression site. The research revea...
KEY FINDING: The number of CD11b positive microglia/macrophages increased with the severity of spinal cord compression.
J Korean Neurosurg Soc, 2013 • June 1, 2013
This study investigated the alterations in the expression of key regulators of neuronal development, survival, and death following SCI in mice. The findings revealed a significant increase in BDNF exp...
KEY FINDING: BDNF expression was significantly elevated in the SCI group compared to the control group at 2 weeks after SCI.
Crit Care Med, 2014 • June 1, 2014
This study compares the dynamic systemic inflammatory responses of TSCI vs. non-SCI patients, suggesting a key role for IP-10 in driving systemic IL-10 and morbidity. The systemic inflammatory respons...
KEY FINDING: Circulating IL-10 was significantly elevated in thoraco-cervical TSCI vs. non-SCI, whereas IL-1β, sIL-2Rα, IL-4, IL-5, IL-7, IL-13, IL-17, MIP-1α and -1β, GM-CSF, and IFN-γ were significantly reduced in TSCI vs. non-SCI.
Physiol Rep, 2014 • February 1, 2014
This study demonstrated that a low force single twitch stimulation protocol fatigued the human chronically paralyzed muscle. The fatigue index, the potentiation index, and speed properties responded i...
KEY FINDING: Low force stimulation (3 Hz) caused fatigue in chronically paralyzed quadriceps muscles of people with SCI, while the quadriceps of people without paralysis were not fatigued.
Cell Death and Disease, 2025 • January 29, 2025
The study demonstrates that the nuclear orphan receptor NR2F6 represses the expression of the activating receptor NKp46, an established key player in NK cell-mediated cytotoxicity during infection and...
KEY FINDING: NR2F6 represses the expression of the activating receptor NKp46, a key player in NK cell-mediated cytotoxicity.
Neural Regeneration Research, 2014 • February 1, 2014
The Olig family, including Olig1, Olig2, and Olig3, are critical transcription factors involved in neural cell subtype selection during central nervous system development. These factors play significa...
KEY FINDING: Olig1 and Olig2 are essential for oligodendrocyte differentiation and maturation, with Olig2 acting as an early-stage factor and Olig1 playing a critical role in later stages of myelin formation.
JOURNAL OF CLINICAL MICROBIOLOGY, 1989 • July 1, 1989
This study examined the duration of Klebsiella pneumoniae colonization in male patients with spinal cord injury. Colonization, defined as persistence of the same serotype, occurred for up to 55 days i...
KEY FINDING: Klebsiella pneumoniae colonization can persist for up to 55 days in spinal cord injury patients.
JOURNAL OF CLINICAL MICROBIOLOGY, 1997 • September 1, 1997
This study investigated the genetic diversity of Klebsiella pneumoniae isolates from patients with and without spinal cord injuries (SCI) to understand the recurrence of urinary tract infections (UTIs...
KEY FINDING: The RD6 genotype of K. pneumoniae was the most common cause of UTIs in SCI patients and was implicated in recurrent infections.