Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 341-350 of 1,651 results
Acta Neurochirurgica, 2021 • April 5, 2021
Herein, we found that BMSC-Shh-Exos were able to effectively protect rats against SCI-associated pathology by promoting neuronal functional recovery, survival, and by inhibiting the excessive activati...
KEY FINDING: Both BMSC-Exo and BMSC-Shh-Exo preparations significantly increased Shh expression in the spinal cord of SCI model rats and improved BBB scores in these treated animals.
Military Med Res, 2021 • May 12, 2021
This is a correction article addressing errors in figures in a previous publication regarding the conversion of astrocytes to motor neuron-like cells using small molecules. The corrected figures and s...
KEY FINDING: Small molecules can induce morphological changes in human astrocytes, converting them into neuron-like cells.
PNAS, 2021 • April 7, 2021
This study presents the chromosome-level assembly of the giant axolotl genome, providing a valuable resource for understanding genome organization, evolution, and gene regulation in this important mod...
KEY FINDING: The chromosome-scale assembly of the 32 Gb axolotl genome was achieved using Hi-C contact data.
Molecular Neurobiology, 2021 • April 15, 2021
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. Conditional mouse mutants have revealed the functional significance of neuronal and glia...
KEY FINDING: FGFs play a crucial role in the regeneration and repair of the nervous system, with FGFR1 and FGFR2 stimulation inducing neural tissue regeneration in planarians and vertebrate embryos.
Front. Cell Dev. Biol., 2021 • April 1, 2021
This study investigates the changes in gene expressions and DNA methylation during TSC derivation from NF, NT, and SNT blastocysts, identifying a set of 75 TFs whose transcription profiles can infer t...
KEY FINDING: Seventy-five transcription factors (TFs) are continuously upregulated during NF TSC derivation, and their transcription profiles can infer the time course of NF, but not NT, TSC derivation.
Molecular Therapy, 2021 • August 1, 2021
This study demonstrates that Gsx1 expression increases NSPCs and the generation of specific interneuron subtypes, including vGlut2+ and ChAT+ interneurons, and 5-HT neuronal activity, while reducing i...
KEY FINDING: Gsx1 expression increases the number of NSPCs in a mouse model of lateral hemisection SCI during the acute stage.
eLife, 2021 • May 14, 2021
This study investigates the mechanisms underlying spinal cord regeneration in axolotls, focusing on the spatiotemporal pattern of cell proliferation. It demonstrates that the regenerative response is ...
KEY FINDING: Spinal cord regeneration is consistent with a signal that recruits ependymal cells during approximately 85 hours after amputation within approximately 830 μm of the injury.
Neural Regen Res, 2021 • April 23, 2021
This study demonstrates that Id2 can accelerate axonal regeneration, promote neuromuscular reinnervation, and enhance functional improvement following sciatic nerve injury in mice. The researchers use...
KEY FINDING: Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve.
Neural Regeneration Research, 2021 • December 1, 2021
This study investigates the interaction between spastin and CRMP3 in spinal cord injury repair, finding that CRMP3 expression is inversely associated with SCI severity. The research demonstrates that ...
KEY FINDING: Mass spectrometry identified the role of CRMP3 in the spinal cord injury repair process.
PLoS Genetics, 2021 • April 29, 2021
The study establishes an efficient sCrRNA screening paradigm that involves a pre-screening step to compensate for inherent variability in sCrRNA activity and to identify highly active guides (haCRs) f...
KEY FINDING: Rapid screening method identifies genes necessary for nerve connection repair and inflammation control after spinal cord injury in zebrafish.