Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 21-30 of 5,253 results
The Journal of Spinal Cord Medicine, 2023 • May 10, 2022
This open-label exploratory study assessed the tolerability and potential efficacy of MLC601/MLC901 (NeuroAiD) combined with rehabilitation in patients with severe spinal cord injury (SCI). The study ...
KEY FINDING: MLC601/MLC901 was found to be safe as an add-on treatment in severe SCI, with no adverse events considered related to the drug.
Global Spine Journal, 2024 • February 1, 2024
The study aimed to address the inconsistency in the naming and definition of cervical myelopathy caused by degenerative changes to the spine. Through a structured, iterative consensus process involvin...
KEY FINDING: The study selected 'Degenerative Cervical Myelopathy' (DCM) as the unifying term for the condition.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
This study investigated the effects of warm acupuncture (WA) therapy on neuronal apoptosis and recovery after spinal cord injury (SCI) in rats, focusing on the role of the ERK signaling pathway. The r...
KEY FINDING: Warm acupuncture (WA) treatment significantly raised the Basso, Beattie & Bresnahan locomotor rating scale (BBB scale) of SCI rats from 7 to 14 days after SCI, indicating improved motor function.
Am J Phys Med Rehabil, 2023 • June 1, 2023
This cross-sectional study evaluated the effect of surface neuromuscular electrical stimulation (NMES) of paralyzed lower-limb muscles on energy expenditure in individuals with spinal cord injury (SCI...
KEY FINDING: NMES significantly increases energy expenditure compared to sitting without NMES in individuals with SCI.
Neural Regeneration Research, 2023 • April 1, 2023
This review summarizes the progress in reprogramming astrocytes into neurons in vivo in animal models of various CNS conditions. The focus is on spinal cord injury, brain injury, Huntington’s disease,...
KEY FINDING: Astrocytes in the mature CNS can be reprogrammed into functional neurons in vivo, offering a potential avenue for nerve regeneration.
Behav Brain Res, 2023 • April 12, 2023
The study used machine-learning-based video analysis to quantify fine-grained finger behavior during a sugar pellet grasping task after a unilateral cervical DCL. The analysis identified a change in d...
KEY FINDING: Cervical dorsal column lesion (DCL) produces a change in digit orientation from lateral to vertical.
Neural Regeneration Research, 2023 • October 10, 2022
The study investigated the effect of double-target NC-MS on rats with incomplete SCI, finding that it improved motor function and promoted recovery of the descending motor pathway. NC-MS treatment att...
KEY FINDING: Double-target NC-MS treatment improved motor function in rats with incomplete SCI, as evidenced by increased BBB scores and inclined-plane angles.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study evaluated the efficacy of intravesical botulinum toxin type A (BTX-A) injections for neurogenic detrusor overactivity (NDO) in reducing the frequency and severity of autonomic dysreflexia (...
KEY FINDING: BTX-A injection decreased the maximum detrusor pressure (Pdetmax) significantly.
International Journal of Spine Surgery, 2022 • November 21, 2022
This study examined the effect of smoking on motor recovery in patients with American Spinal Injury Association (ASIA) grade D cervical traumatic spinal cord injury (TSCI). The research found that pat...
KEY FINDING: Smokers had worse improvement in motor score at 1 year compared to nonsmokers (4.61 vs 7.99, P = 0.019).
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This scoping review examines current research on physical and cognitive impairment in SCI patients to identify research gaps and encourage new studies on cognitive frailty in this population. The revi...
KEY FINDING: Neuroinflammation is a potential mechanism for cognitive impairment among patients with SCI. The review indicates that pro-inflammatory mediators and markers of glial activation are major factors contributing to further cognitive decline and dementia.