Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 31-40 of 5,253 results
Neural Regeneration Research, 2023 • October 11, 2022
This study investigates the role of thrombin in regulating cholesterol metabolism in astrocytes following spinal cord injury (SCI) in rats. The results demonstrate that SCI-induced thrombin activation...
KEY FINDING: Spinal cord injury increases thrombin and CH25H expression in rat astrocytes.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
A 56-year-old female veteran with multiple sclerosis (MS) implemented a time-restricted eating (TRE) program, eating all calories within a 6-hour window, to combat weight gain. Over 6 months, the pati...
KEY FINDING: The patient experienced significant weight loss (7.2 kg based on self-report, 9.5 kg from 1 year prior based on Veterans Affairs (VA) measurements).
Asian Spine Journal, 2023 • April 1, 2023
The study evaluated postoperative functional status using FIM-L, WISCI II, ASIA-LEMS, and ASIA-LESS scores, finding that independent walkers at 2 weeks had better lower-limb and sensory function recov...
KEY FINDING: 71% and 43% of participants were nonindependent ambulators at 1 week and 2 weeks postoperatively, respectively.
The Neuroscientist, 2024 • January 1, 2023
This review explores the mechanisms underlying the effects of spinal cord stimulation (SCS) for autonomic recovery following spinal cord injury (SCI). Two plausible mechanisms are discussed: activatio...
KEY FINDING: SCS likely activates the somatoautonomic reflex arc by stimulating primary afferent fibers, spinal interneurons, and autonomic efferent pathways, resulting in targeted responses in visceral organs.
Molecular Psychiatry, 2023 • February 1, 2023
The study examined racial/ethnic differences in neurophysiological reactivity and connectivity following trauma exposure using fMRI and psychophysiology. Findings revealed that Black and Hispanic indi...
KEY FINDING: Black participants showed lower tonic skin conductance levels and startle compared to White participants, but no differences were observed in physiological reactions to threat.
Neural Regeneration Research, 2023 • December 21, 2022
This article reviews research on the mechanistic roles of purinergic receptors in spinal cord injury, highlighting the potential role of purinergic receptors as interventional targets for neural repai...
KEY FINDING: Activation of adenosine A1 and A3 receptors can exert neuroprotective effects after CNS injury by inhibiting glutamate release and reducing Ca2+ accumulation.
Neural Regeneration Research, 2023 • December 21, 2022
This study investigates the role of macrophage migration inhibitory factor (MIF) in the production of the chemokine CCL2 by astrocytes following spinal cord injury (SCI). The findings demonstrate that...
KEY FINDING: MIF levels significantly increase at the lesion site after SCI, coinciding with elevated CCL2 production.
Neural Regeneration Research, 2023 • October 11, 2022
This study explored the protective role of PARP14 in SCI, finding that PARP14 expression increases at the injury site in a mouse model of SCI, and its knockdown worsens SCI. Both in vivo and in vitro ...
KEY FINDING: PARP14 expression is upregulated in spinal cord tissues after SCI, suggesting a compensatory mechanism.
Global Spine Journal, 2024 • July 1, 2024
This study aimed to compare the efficacy of riluzole, methylprednisolone (MPS), and their combination in treating acute spinal trauma in a rat model, using electrophysiological and histopathological a...
KEY FINDING: Electrophysiologically, no treatment provided significant improvement compared to the control group in terms of latency and amplitude.
IBRO Neuroscience Reports, 2023 • January 1, 2023
This review explores the potential role of silent synapses in corticospinal motor circuit neuroplasticity following spinal cord injury (SCI) and how neuromodulation can be used to facilitate functiona...
KEY FINDING: Spinal cord injury (SCI) leads to severe sensorimotor dysfunction by damaging the corticospinal system, but the CNS possesses considerable plasticity that can be harnessed for recovery.