Neurology Research

KEY FINDING: Astrocyte diversity is observed in various CNS pathologies, including ischemic stroke, demyelination, and traumatic injury, but the extent to which this diversity represents heterogeneity or plasticity remains unclear.

KEY FINDING: Axis cylinders can be successfully cultivated in vitro from the brains of chick embryos, young cats, rabbits, and dogs.

KEY FINDING: Anatomical continuity is rapidly restored after complete spinal cord transection in larval zebrafish.

KEY FINDING: Disrupting local bioelectric signals in the developing neural tube increases apoptosis and decreases proliferation, leading to brain mispatterning.

KEY FINDING: Thoracic spinal cord contusion injury induces complete paresis of both hindlimbs in rats.

KEY FINDING: NMNAT2 is essential for axon extension in both the peripheral and central nervous systems during development. NMNAT2-deficient embryos exhibit truncated axons, indicating a failure of axons to extend properly.

KEY FINDING: CHL1-deficient mice showed decreased preferential motor re-innervation, indicating reduced precision in motor axon targeting after nerve injury.

KEY FINDING: Multi-disciplinary approaches are critical for therapeutic techniques to realize their full potential, suggesting that well-timed, goal-directed therapy and positive feedback mechanisms are necessary for axonal sprouting and lasting functional improvement.

KEY FINDING: Impaired macrophage migration leads to a more widespread distribution of astrocytes and an increased scar area after spinal cord injury.

KEY FINDING: DCM leads to a significant reduction in locomotor activity and muscle strength in mice.